Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 19/20 | 0.53 |
| ▸ | PPARG | P37231 | 17/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 10/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.53 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10184560 | 0.95 | PPARA (0.53) | PPARAPPARGCYP2C9KCNH2SLC2A1 | |
| SCHEMBL10184533 | 0.90 | PPARA (0.55) | PPARAPPARGCYP2C9KCNH2SLC2A1 | |
| SCHEMBL10186223 | 0.89 | PPARA (0.55) | PPARAPPARGCYP2C9KCNH2 | |
| SCHEMBL10185897 | 0.78 | PPARA (0.48) | PPARAPPARGCYP2C9KCNH2SLC2A1 | |
| SCHEMBL6073127 | 0.77 | PPARA (0.52) | PPARAPPARGCYP2C9KCNH2SLC2A1 | |
| SCHEMBL6502061 | 0.75 | PPARA (0.58) | PPARAPPARGCYP2C9KCNH2SLC2A1 | |
| SCHEMBL13899279 | 0.75 | PPARA (0.54) | PPARAPPARGCYP2C9KCNH2SLC2A1 | |
| SCHEMBL5428359 | 0.74 | PPARA (0.60) | PPARAPPARGCYP2C9KCNH2 | |
| SCHEMBL5432380 | 0.74 | PPARG (0.49) | PPARAPPARGCYP2C9KCNH2SLC2A1 | |
| SCHEMBL6504749 | 0.73 | PPARA (0.68) | PPARAPPARGCYP2C9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531810-B1 | SUBSTITUTED HETEROCYCLIC DERIVATIVES USEFUL AS ANTIDIABETIC AND ANTIOBESITY AGENTS AND METHOD | BRISTOL MYERS SQUIBB CO (US) | 2012-02-01 | — | — | EP | disclosed |