Sugi Predict

Sugi Predict / Compounds / SCHEMBL10186609

SCHEMBL10186609

SCHEMBL10186609

COCCOc1cccc(OC)c1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPK1 P28482 4/20 0.68
▸ NPSR1 Q6W5P4 2/20 0.58
▸ MAOB P27338 4/20 0.56
▸ MTNR1A P48039 1/20 0.56
▸ MTNR1B P49286 1/20 0.56
▸ TSHR P16473 4/20 0.55
▸ LMNA P02545 1/20 0.55
▸ ALDH1A1 P00352 3/20 0.54
▸ CYP1A2 P05177 2/20 0.53
▸ CYP2C19 P33261 2/20 0.53
▸ CYP2D6 P10635 1/20 0.53
▸ MEN1 O00255 1/20 0.53
▸ CYP3A4 P08684 1/20 0.53
▸ CYP2C9 P11712 1/20 0.53
▸ RECQL P46063 1/20 0.53
▸ KMT2A Q03164 1/20 0.53
▸ L3MBTL1 Q9Y468 1/20 0.53
▸ ALOX15 P16050 1/20 0.53
▸ HSD17B10 Q99714 1/20 0.53
▸ SMN1; SMN2 Q16637 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1729519 0.94 MAPK1 (0.75) MAPK1NPSR1MAOBMTNR1AMTNR1B
SCHEMBL15723552 0.94 MAPK1 (0.58) MAPK1NPSR1MAOBMTNR1AMTNR1B
SCHEMBL16668774 0.88 TSHR (0.55) MAPK1NPSR1TSHRLMNAALDH1A1
SCHEMBL25981244 0.88 MAPK1 (0.53) MAPK1NPSR1MTNR1AMTNR1BTSHR
SCHEMBL3920395 0.88 MAPK1 (0.68) MAPK1NPSR1MAOBMTNR1AMTNR1B
SCHEMBL10597796 0.88 MAPK1 (0.68) MAPK1NPSR1MAOBMTNR1AMTNR1B
SCHEMBL12126283 0.86 MAPK1 (0.70) MAPK1NPSR1TSHRLMNAALDH1A1
SCHEMBL4568919 0.86 MAPK1 (0.56) MAPK1NPSR1TSHRLMNAALDH1A1
SCHEMBL11312715 0.85 MAPK1 (0.65) MAPK1NPSR1MAOBMTNR1AMTNR1B
SCHEMBL16601862 0.84 MAPK1 (0.58) MAPK1TSHRALDH1A1CYP1A2CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240139164-A1 RAPAMYCIN ANALOGS AND USES THEREOF JANSSEN PHARMACEUTICA NV (BE) 2024-05-02 — — US disclosed
US-20240131012-A1 RAPAMYCIN ANALOGS AND USES THEREOF JANSSEN PHARMACEUTICA NV (BE) 2024-04-25 — — US disclosed
US-11819476-B2 Rapamycin analogs and uses thereof JANSSEN PHARMACEUTICA NV (BE) 2023-11-21 — — US disclosed
US-11819476-B2 Rapamycin analogs and uses thereof JANSSEN PHARMACEUTICA NV (BE) 2023-11-21 — — US disclosed
US-11819476-B2 Rapamycin analogs and uses thereof JANSSEN PHARMACEUTICA NV (BE) 2023-11-21 — — US disclosed
CN-115209897-A Rapamycin analogs and uses thereof 安纳库利亚治疗公司 2022-10-18 — — CN disclosed
EP-4069223-A1 RAPAMYCIN ANALOGS AND USES THEREOF Anakuria Therapeutics, Inc. (US) 2022-10-12 — — EP disclosed
US-20210186935-A1 RAPAMYCIN ANALOGS AND USES THEREOF JANSSEN PHARMACEUTICA NV (BE) 2021-06-24 — — US disclosed
US-20210186935-A1 RAPAMYCIN ANALOGS AND USES THEREOF JANSSEN PHARMACEUTICA NV (BE) 2021-06-24 — — US disclosed
WO-2021113665-A1 RAPAMYCIN ANALOGS AND USES THEREOF NAVITOR PHARMACEUTICALS, INC. (US) 2021-06-10 — — WO disclosed
US-8933229-B2 8-azabicyclo[3.2.1]octane-8-carboxamide derivative SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) 2015-01-13 — — US disclosed
US-8933229-B2 8-azabicyclo[3.2.1]octane-8-carboxamide derivative SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) 2015-01-13 — — US disclosed
CN-102333769-B Derivatives of 2-pyridin-2-yl-pyrazol-3 (2H) -one, preparation thereof, and therapeutic use as HIF activators SANOFI AVENTIS 2014-08-27 — — CN disclosed
EP-2500345-A1 8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXAMIDE DERIVATIVE Dainippon Sumitomo Pharma Co., Ltd. (JP) 2012-09-19 — — EP disclosed
US-20120225876-A1 8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXAMIDE DERIVATIVE DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2012-09-06 — — US disclosed
US-20120225876-A1 8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXAMIDE DERIVATIVE DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2012-09-06 — — US disclosed
US-20120046293-A1 RENIN INHIBITORS MERCK FROSST CANADA LTD. (CA) 2012-02-23 — — US disclosed
CN-102333769-A Derivatives of 2-pyridin-2-yl-pyrazol-3 (2H) -one, preparation thereof, and therapeutic use as HIF activators SANOFI AVENTIS 2012-01-25 — — CN disclosed
CN-101151246-B 1-benzylindole-2-carboxamide derivatives ORGANON NV 2011-04-13 — — CN disclosed
CN-101151246-A 1-benzylindole-2-carboxamide derivatives ORGANON NV (NL) 2008-03-26 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120046293-A1 RENIN INHIBITORS REN, ACE, AGTR1 MAPK1 830/4885NPSR1 1723/4885MAOB 1521/4885
US-20210186935-A1 RAPAMYCIN ANALOGS AND USES THEREOF RICTOR, MTOR, RPTOR MAPK1 1669/4885NPSR1 2376/4885MAOB 4115/4885
US-20240139164-A1 RAPAMYCIN ANALOGS AND USES THEREOF RICTOR, MTOR, RPTOR MAPK1 1669/4885NPSR1 2376/4885MAOB 4115/4885
US-20120225876-A1 8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXAMIDE DERIVATIVE HDAC10, HDAC11, HDAC1 MAPK1 622/4885NPSR1 2006/4885MAOB 53/4885
US-20240131012-A1 RAPAMYCIN ANALOGS AND USES THEREOF RICTOR, MTOR, RPTOR MAPK1 1669/4885NPSR1 2376/4885MAOB 4115/4885
US-11819476-B2 Rapamycin analogs and uses thereof RICTOR, MTOR, RPTOR MAPK1 504/4885NPSR1 3210/4885MAOB 4268/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.