SCHEMBL10187598

SCHEMBL10187598

CNCC(=O)NC1C(O)CC(OP(=O)(O)OCC2OC(n3ccc(N)nc3=O)C(O)C2O)(C(=O)O)OC1[C@H](O)[C@H](O)CO

nearest known ligand 0.50

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ST6GAL1 P15907 10/20 0.46
P2RY2 P41231 3/20 0.44
P2RY4 P51582 2/20 0.43
P2RY6 Q15077 2/20 0.43
TSHR P16473 1/20 0.41
GLA P06280 1/20 0.41
CD22 P20273 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14027764 1.00 ST6GAL1 (0.46) ST6GAL1P2RY2P2RY4P2RY6TSHR
SCHEMBL18494422 0.95 ST6GAL1 (0.47) ST6GAL1P2RY2P2RY4P2RY6TSHR
SCHEMBL14414545 0.94 ST6GAL1 (0.40) ST6GAL1P2RY2P2RY4P2RY6CD22
SCHEMBL10187590 0.94 ST6GAL1 (0.45) ST6GAL1P2RY2P2RY4P2RY6CD22
SCHEMBL10044124 0.94 ST6GAL1 (0.46) ST6GAL1P2RY2P2RY4P2RY6TSHR
SCHEMBL29397564 0.94 ST6GAL1 (0.48) ST6GAL1P2RY2P2RY4P2RY6CD22
SCHEMBL29397212 0.94 ST6GAL1 (0.48) ST6GAL1P2RY2P2RY4P2RY6CD22
SCHEMBL18495200 0.93 ST6GAL1 (0.47) ST6GAL1P2RY2P2RY4P2RY6TSHR
SCHEMBL12495844 0.93 ST6GAL1 (0.47) ST6GAL1P2RY2P2RY4P2RY6TSHR
SCHEMBL16093276 0.93 ST6GAL1 (0.47) ST6GAL1P2RY2P2RY4P2RY6TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170136104-A1 GLYCOPEGYLATED FACTOR IX NOVO NORDISK AS (DK) 2017-05-18 US disclosed
US-20170007712-A1 GLYCOPEGYLATION METHODS AND PROTEINS/PEPTIDES PRODUCED BY THE METHODS NOVO NORDISK A/S (DK) 2017-01-12 US disclosed
US-20160361427-A1 Glycopegylated Factor IX NOVO NORDISK AS (DK) 2016-12-15 US disclosed
US-20160200795-A1 FACTOR VIII: REMODELING AND GLYCOCONJUGATION OF FACTOR VIII NOVO NORDISK A/S (DK) 2016-07-14 US disclosed
US-20160193353-A1 FACTOR VIII: REMODELING AND GLYCOCONJUGATION OF FACTOR VIII NOVO NORDISK A/S (DK) 2016-07-07 US disclosed
US-20160184412-A1 Glycopegylated Factor IX NOVO NORDISK AS (DK) 2016-06-30 US disclosed
US-20160158319-A1 REMODELING AND GLYCOPEGYLATION OF FIBROBLAST GROWTH FACTOR (FGF) NOVO NORDISK A/S (DK) 2016-06-09 US disclosed
US-20150343080-A1 GLYCOPEGYLATION METHODS AND PROTEINS/PEPTIDES PRODUCED BY THE METHODS NOVO NORDISK AS (DK) 2015-12-03 US disclosed
US-9200049-B2 Remodeling and glycopegylation of fibroblast growth factor (FGF) NOVO NORDISK A/S (DK) 2015-12-01 US disclosed
US-9187532-B2 Glycosylation of peptides via O-linked glycosylation sequences NOVO NORDISK A/S (DK) 2015-11-17 US disclosed
US-7276475-B2 Remodeling and glycoconjugation of peptides NEOSE TECHNOLOGIES, INC. (US) 2007-10-02 US disclosed
US-7265084-B2 Glycopegylation methods and proteins/peptides produced by the methods NEOSE TECHNOLOGIES, INC. (US) 2007-09-04 US disclosed
US-7226903-B2 Interferon beta: remodeling and glycoconjugation of interferon beta NEOSE TECHNOLOGIES, INC. (US) 2007-06-05 US disclosed
US-20070059275-A1 Antibody toxin conjugates NOVO NORDISK A/S (DK) 2007-03-15 US disclosed
US-20070042458-A1 ERYTHROPOIETIN: REMODELING AND GLYCOCONJUGATION OF ERYTHROPOIETIN NEOSE TECHNOLOGIES, INC. 2007-02-22 US disclosed
US-7179617-B2 Forming a convalent conjugate of a Factor IX peptide, removing X2 or a saccharyl subunit thereof from peptide forming a truncated glycan; contacting truncated glycan with glycosyltransferase and modified sugar donor under conditions suitable for glycosyltransferase to transfer a modified sugar moiety NEOSE TECHNOLOGIES, INC. (US) 2007-02-20 US disclosed
US-7173003-B2 Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF NEOSE TECHNOLOGIES, INC. (US) 2007-02-06 US disclosed
US-20070026485-A1 Glycopegylation methods and proteins/peptides produced by the methods NEOSE TECHNOLOGIES, INC. (US) 2007-02-01 US disclosed
US-20070027068-A1 Erythropoietin: remodeling and glycoconjugation of erythropoietin NOVO NORDISK A/S (DK) 2007-02-01 US disclosed
US-7157277-B2 Factor VIII remodeling and glycoconjugation of Factor VIII NEOSE TECHNOLOGIES, INC. (US) 2007-01-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160158319-A1 REMODELING AND GLYCOPEGYLATION OF FIBROBLAST GROWTH FACTOR (FGF) FGF2, FGF1, FGFR1 ST6GAL1 48/4885P2RY2 3944/4885P2RY4 3930/4885
US-20160200795-A1 FACTOR VIII: REMODELING AND GLYCOCONJUGATION OF FACTOR VIII F13B, F8, F13A1 ST6GAL1 30/4885P2RY2 4558/4885P2RY4 4406/4885
US-20070027068-A1 Erythropoietin: remodeling and glycoconjugation of erythropoietin EPOR, HBG2, HAMP ST6GAL1 410/4885P2RY2 4650/4885P2RY4 4645/4885
US-20160193353-A1 FACTOR VIII: REMODELING AND GLYCOCONJUGATION OF FACTOR VIII F13B, F8, F13A1 ST6GAL1 30/4885P2RY2 4558/4885P2RY4 4406/4885
US-20160361427-A1 Glycopegylated Factor IX F9, F13A1, F13B ST6GAL1 22/4885P2RY2 4815/4885P2RY4 4805/4885
US-20070026485-A1 Glycopegylation methods and proteins/peptides produced by the methods PTMS, ANPEP, NGLY1 ST6GAL1 57/4885P2RY2 4763/4885P2RY4 4768/4885
US-20170136104-A1 GLYCOPEGYLATED FACTOR IX F9, F13A1, F13B ST6GAL1 22/4885P2RY2 4815/4885P2RY4 4805/4885
US-20170007712-A1 GLYCOPEGYLATION METHODS AND PROTEINS/PEPTIDES PRODUCED BY THE METHODS PTMS, ANPEP, NGLY1 ST6GAL1 57/4885P2RY2 4763/4885P2RY4 4768/4885
US-20070042458-A1 ERYTHROPOIETIN: REMODELING AND GLYCOCONJUGATION OF ERYTHROPOIETIN EPOR, HBG2, HAMP ST6GAL1 410/4885P2RY2 4650/4885P2RY4 4645/4885
US-20160184412-A1 Glycopegylated Factor IX F9, F13A1, F13B ST6GAL1 22/4885P2RY2 4817/4885P2RY4 4809/4885
US-20150343080-A1 GLYCOPEGYLATION METHODS AND PROTEINS/PEPTIDES PRODUCED BY THE METHODS PTMS, ANPEP, NGLY1 ST6GAL1 57/4885P2RY2 4763/4885P2RY4 4768/4885
US-20070059275-A1 Antibody toxin conjugates CD47, ANTXR2, STT3A ST6GAL1 9/4885P2RY2 3238/4885P2RY4 3099/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.