Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRC | P08575 | 1/20 | 0.53 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.47 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8288837 | 0.85 | PTPRC (0.52) | PTPRCPTPN2PTPN1CXCR2ANO1 | |
| SCHEMBL13151117 | 0.85 | PTPRC (0.53) | PTPRCPTPN2PTPN1CXCR2ANO1 | |
| SCHEMBL10189463 | 0.81 | PTPRC (0.48) | PTPRCPTPN2PTPN1CXCR2ADORA1 | |
| SCHEMBL8288687 | 0.77 | PTPRC (0.52) | PTPRCPTPN2PTPN1ANO1FLT3 | |
| SCHEMBL8290465 | 0.76 | FLT3 (0.68) | PTPRCPTPN2PTPN1ANO1FLT3 | |
| SCHEMBL8289857 | 0.75 | ADORA1 (0.63) | PTPRCPTPN2PTPN1ANO1ADORA1 | |
| SCHEMBL14136697 | 0.74 | KCNH2 (0.49) | PTPRCPTPN2PTPN1CXCR2FLT3 | |
| SCHEMBL349390 | 0.74 | KCNH2 (0.62) | PTPRCPTPN2PTPN1CXCR2ANO1 | |
| SCHEMBL10189497 | 0.74 | ALDH1A1 (0.47) | ANO1FLT3KDM4EKMT2AMEN1 | |
| SCHEMBL14136793 | 0.74 | FLT3 (0.52) | PTPRCPTPN2PTPN1CXCR2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8329907-B2 | Autotaxin inhibitors | MERCK PATENT GMBH (DE) | 2012-12-11 | — | — | US | disclosed |
| US-20120015976-A1 | AUTOTAXIN INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANK TER HAFTUNG (DE) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015976-A1 | AUTOTAXIN INHIBITORS | ENPP2, PLA2G12A, LPCAT1 | PTPRC 1727/4885PTPN2 2318/4885PTPN1 2080/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.