Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 7/20 | 0.38 |
| ▸ | IL6ST | P40189 | 1/20 | 0.37 |
| ▸ | GLS | O94925 | 2/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12973848 | 0.86 | NAAA (0.46) | LMNANPC1TP53HPGDRAB9A | |
| SCHEMBL27967862 | 0.86 | NAAA (0.46) | LMNANPC1TP53HPGDRAB9A | |
| SCHEMBL27967864 | 0.86 | NAAA (0.46) | LMNANPC1TP53HPGDRAB9A | |
| SCHEMBL3192886 | 0.86 | NAAA (0.46) | LMNANPC1TP53HPGDRAB9A | |
| SCHEMBL23699056 | 0.86 | HPGD (0.45) | LMNANPC1TP53HPGDRAB9A | |
| SCHEMBL12634643 | 0.86 | HPGD (0.45) | LMNANPC1TP53HPGDRAB9A | |
| SCHEMBL4684591 | 0.86 | HPGD (0.45) | LMNANPC1TP53HPGDRAB9A | |
| SCHEMBL21447357 | 0.86 | HPGD (0.45) | LMNANPC1TP53HPGDRAB9A | |
| SCHEMBL4684580 | 0.86 | HPGD (0.45) | LMNANPC1TP53HPGDRAB9A | |
| SCHEMBL23699057 | 0.86 | HPGD (0.45) | LMNANPC1TP53HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012012314-A1 | NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | disclosed |
| WO-2011137054-A1 | NOVEL BETA 3 ADRENERGIC RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2011-11-03 | — | — | WO | disclosed |
| WO-2011043942-A1 | COMBINATION THERAPY USING A BETA 3 ADRENERGIC RECEPTOR AGONIST AND AN ANTIMUSCARINIC AGENT | MERCK SHARP & DOHME CORP. (US) | 2011-04-14 | — | — | WO | disclosed |