Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 12/20 | 0.66 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 4/20 | 0.44 |
| ▸ | MAOB | P27338 | 4/20 | 0.44 |
| ▸ | PRKCI | P41743 | 1/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10190634 | 0.86 | GRM5 (0.75) | GRM5MAOAMAOBPRKCIHSD17B1 | |
| SCHEMBL10190633 | 0.85 | GRM5 (0.70) | GRM5MAOAMAOBPRKCIHSD17B1 | |
| SCHEMBL10190645 | 0.82 | GRM5 (0.68) | GRM5MAOAMAOBPRKCIHSD17B1 | |
| SCHEMBL504632 | 0.80 | GRM5 (1.00) | GRM5NR3C2 | |
| SCHEMBL10190638 | 0.78 | GRM5 (0.64) | GRM5MAOAMAOBPRKCIHSD17B1 | |
| SCHEMBL315877 | 0.78 | MAOA (0.61) | GRM5MAOAMAOBPRKCIHSD17B1 | |
| SCHEMBL24570906 | 0.77 | GRM5 (0.68) | GRM5HSD17B1 | |
| SCHEMBL30584430 | 0.77 | GRM5 (0.68) | GRM5HSD17B1 | |
| SCHEMBL10190614 | 0.76 | GRM5 (1.00) | GRM5MAOAMAOBPRKCI | |
| SCHEMBL10190640 | 0.75 | GRM5 (0.70) | GRM5MAOAMAOBPRKCIHSD17B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028955-A1 | BICYCLIC MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | VANDERBILT UNIVERSITY | 2012-02-02 | — | — | US | disclosed |
| US-20120028956-A1 | BICYCLIC MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | VANDERBILT UNIVERSITY | 2012-02-02 | — | — | US | disclosed |
| US-8034806-B2 | Bicyclic mGluR5 positive allosteric modulators and methods of making and using same | VANDERBILT UNIVERSITY (US) | 2011-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028955-A1 | BICYCLIC MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | GRM5, GRIK5, GRM1 | GRM5 1/4885NR3C2 810/4885MAOA 3858/4885 |
| US-20120028956-A1 | BICYCLIC MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | GRM5, GRIK5, GRM1 | GRM5 1/4885NR3C2 810/4885MAOA 3858/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.