Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | BRD2 | P25440 | 1/20 | 0.35 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.35 |
| ▸ | PHGDH | O43175 | 2/20 | 0.34 |
| ▸ | WDR5 | P61964 | 3/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL347680 | 0.72 | DGAT2 (0.55) | DGAT2CYP2C9P2RX3ALDH1A1LMNA | |
| SCHEMBL16504277 | 0.71 | CYP2C9 (0.41) | DGAT2CYP2C9P2RX3ALDH1A1LMNA | |
| SCHEMBL19773485 | 0.70 | DGAT2 (0.44) | DGAT2CYP2C9P2RX3ALDH1A1LMNA | |
| SCHEMBL21092146 | 0.69 | P2RX3 (0.54) | DGAT2CYP2C9P2RX3ALDH1A1LMNA | |
| SCHEMBL25780851 | 0.68 | KMT2A (0.65) | KMT2AMEN1HTTALDH1A1LMNA | |
| SCHEMBL21945920 | 0.68 | KMT2A (0.65) | KMT2AMEN1HTTALDH1A1LMNA | |
| SCHEMBL13365589 | 0.67 | CYP2C9 (0.38) | DGAT2CYP2C9P2RX3ALDH1A1LMNA | |
| SCHEMBL13092854 | 0.67 | P2RX3 (0.59) | DGAT2CYP2C9P2RX3ALDH1A1LMNA | |
| SCHEMBL452073 | 0.66 | CYP2C9 (0.37) | DGAT2KMT2AMEN1HTTCYP2C9 | |
| SCHEMBL13092755 | 0.64 | CYP2C9 (0.49) | DGAT2CYP2C9P2RX3ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120015052-A1 | P2X3 RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN | MERCK SHARP & DOHME LLC | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015052-A1 | P2X3 RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN | P2RX3, P2RX1, P2RX2 | DGAT2 3948/4885KMT2A 4191/4885MEN1 4860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.