Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 14/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 9/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12163726 | 1.00 | KDM4E (0.38) | KDM4EHSD17B10MEN1KMT2AHTT | |
| SCHEMBL16358105 | 0.94 | KDM4E (0.36) | KDM4EHSD17B10MEN1KMT2AHTT | |
| SCHEMBL381709 | 0.84 | ADORA2B (0.43) | KDM4EHSD17B10MEN1KMT2AMAPT | |
| SCHEMBL252404 | 0.84 | ADORA2B (0.43) | KDM4EHSD17B10MEN1KMT2AMAPT | |
| SCHEMBL3602017 | 0.84 | ADORA2B (0.43) | KDM4EHSD17B10MEN1KMT2AMAPT | |
| SCHEMBL12163724 | 0.84 | MAPT (0.46) | KDM4EHSD17B10MEN1KMT2AHTT | |
| SCHEMBL3304369 | 0.80 | KDM4E (0.34) | KDM4EHSD17B10MEN1KMT2AHTT | |
| SCHEMBL13285361 | 0.78 | ADORA1 (0.48) | KDM4EHSD17B10MEN1KMT2AHTT | |
| SCHEMBL10194182 | 0.78 | ADORA1 (0.48) | KDM4EHSD17B10MEN1KMT2AHTT | |
| SCHEMBL12163870 | 0.77 | ADORA1 (0.45) | KDM4EHSD17B10MEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2235011-B1 | SUBSTITUTED PYRROLO[2, 3-B]AND PYRAZOLO[3, 4-B]PYRIDINES FOR USE AS ADENOSINE RECEPTOR LIGANDS | Bayer Pharma AG (DE) | 2012-01-25 | — | — | EP | disclosed |
| WO-2009015776-A1 | SUBSTITUTED ARYLOXAZOLES AND THE USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-02-05 | — | — | WO | disclosed |