Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ERN1 | O75460 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1019489 | 1.00 | TSHR (0.35) | TSHRPOLBMAPK1TP53GAA | |
| SCHEMBL7331643 | 0.83 | CA1 (0.35) | TSHRPOLBMAPK1TP53CYP3A4 | |
| SCHEMBL22127605 | 0.79 | TSHR (0.37) | TSHRPOLBMAPK1TP53GAA | |
| SCHEMBL6353034 | 0.78 | MAPT (0.38) | GAAALDH1A1HSD17B10KDM4EHPGD | |
| SCHEMBL6154775 | 0.75 | TSHR (0.34) | TSHRPOLBMAPK1TP53GAA | |
| SCHEMBL4033195 | 0.74 | CYP3A4 (0.39) | TSHRPOLBMAPK1TP53GAA | |
| SCHEMBL13278810 | 0.70 | ALDH1A1 (0.36) | TSHRPOLBMAPK1TP53GAA | |
| SCHEMBL11198413 | 0.70 | — | — | |
| SCHEMBL22468826 | 0.69 | TSHR (0.36) | TSHRPOLBMAPK1TP53GAA | |
| SCHEMBL29529763 | 0.69 | TSHR (0.36) | TSHRPOLBMAPK1TP53GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8372863-B2 | Tetrahydro-1H-pyrrolo fused pyridones | MERCK SHARP & DOHME CORP. (US) | 2013-02-12 | — | — | US | disclosed |
| US-20110009406-A1 | TETRAHYDRO-1H-PYRROLO FUSED PYRIDONES | MERCK SHARP & DOHME LLC | 2011-01-13 | — | — | US | disclosed |
| EP-2257171-A1 | TETRAHYDRO-1H-PYRROLO FUSED PYRIDONES | Merck Sharp & Dohme Corp. (US) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009108499-A1 | TETRAHYDRO-1H-PYRROLO FUSED PYRIDONES | MERCK & CO., INC. (US) | 2009-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009406-A1 | TETRAHYDRO-1H-PYRROLO FUSED PYRIDONES | HIF1AN, EGLN2, EGLN3 | TSHR 2318/4885POLB 1334/4885MAPK1 2862/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.