Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ERN1 | O75460 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1019140 | 0.84 | TSHR (0.38) | TSHRTP53ALDH1A1GAARECQL | |
| SCHEMBL22127638 | 0.81 | L3MBTL1 (0.33) | TSHRTP53ALDH1A1GAARECQL | |
| SCHEMBL415009 | 0.80 | MAPT (0.43) | TSHRALDH1A1GAARECQLMEN1 | |
| Hydrochloric Acid SCHEMBL443973 | 0.78 | MAPT (0.44) | TSHRALDH1A1GAAMEN1KMT2A | |
| SCHEMBL6153842 | 0.77 | NPSR1 (0.34) | TSHRALDH1A1GAASMN1; SMN2CYP3A4 | |
| SCHEMBL29529763 | 0.76 | TSHR (0.36) | TSHRTP53ALDH1A1GAARECQL | |
| SCHEMBL22468826 | 0.76 | TSHR (0.36) | TSHRTP53ALDH1A1GAARECQL | |
| SCHEMBL2721962 | 0.76 | TSHR (0.36) | TSHRTP53ALDH1A1GAARECQL | |
| SCHEMBL22127485 | 0.76 | ALDH1A1 (0.33) | TSHRTP53ALDH1A1GAARECQL | |
| SCHEMBL7517130 | 0.76 | TSHR (0.36) | TSHRTP53ALDH1A1GAARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011101304-A2 | PIPERIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-08-25 | — | — | WO | disclosed |
| CN-100415736-C | Quinolylpropylpiperidine derivatives and their use as antimicrobial agents | AVENTIS PHARMA SA (FR) | 2008-09-03 | — | — | CN | disclosed |
| CN-1681801-A | Quinolylpropylpiperidine derivatives and their use as antimicrobial agents | AVENTIS PHARMA SA (FR) | 2005-10-12 | — | — | CN | disclosed |
| US-6841562-B2 | Quinolylpropylpiperidine derivatives, intermediates and compositions containing them, and preparation therefor | AVENTIS PHARMA S.A. (FR) | 2005-01-11 | — | — | US | disclosed |
| US-20040082610-A1 | Quinolylpropylpiperidine derivatives, intermediates and compositions containing them, and preparation therefor | NOVEXEL (FR) | 2004-04-29 | — | — | US | disclosed |
| US-4012392-A | ANALGESICS, MORPHINE ANTAGONISTS | ACF CHEMIEFARMA N.V. (NL) | 1977-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082610-A1 | Quinolylpropylpiperidine derivatives, intermediates and compositions containing them, and preparation therefor | RRS1, MRPL21, FARSB | TSHR 2967/4885TP53 3373/4885ALDH1A1 1452/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.