Sugi Predict

Sugi Predict / Compounds / SCHEMBL10194875

SCHEMBL10194875

SCHEMBL10194875

c1cc(CCN2CCCC2)cc(-n2cc(-c3n[nH]c4ccccc34)nn2)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FGFR1 P11362 2/20 0.42
▸ FLT1 P17948 2/20 0.42
▸ CDC7 O00311 2/20 0.41
▸ ROCK2 O75116 2/20 0.41
▸ MAP4K4 O95819 2/20 0.41
▸ PIM1 P11309 2/20 0.41
▸ CDK2 P24941 2/20 0.41
▸ HIPK2 Q9H2X6 2/20 0.41
▸ IRAK4 Q9NWZ3 2/20 0.41
▸ SIGMAR1 Q99720 4/20 0.41
▸ KCNH2 Q12809 1/20 0.41
▸ L3MBTL3 Q96JM7 1/20 0.40
▸ L3MBTL1 Q9Y468 1/20 0.40
▸ HRH3 Q9Y5N1 3/20 0.39
▸ SLC6A3 Q01959 2/20 0.39
▸ CDK5 Q00535 1/20 0.39
▸ CDK5R1 Q15078 1/20 0.39
▸ GRM4 Q14833 1/20 0.38
▸ TERT O14746 2/20 0.38
▸ PRKACA P17612 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10194695 0.94 FGFR1 (0.45) FGFR1FLT1CDC7ROCK2MAP4K4
SCHEMBL10194729 0.91 LRRK2 (0.45) FGFR1FLT1CDC7ROCK2MAP4K4
SCHEMBL10194692 0.86 SIGMAR1 (0.44) FGFR1FLT1CDC7SIGMAR1
SCHEMBL27945212 0.85 CDC7 (0.41) FGFR1FLT1CDC7ROCK2MAP4K4
SCHEMBL9952277 0.84 NPC1 (0.44) CDC7ROCK2MAP4K4PIM1CDK2
SCHEMBL9953146 0.82 POLB (0.42) CDC7ROCK2MAP4K4PIM1CDK2
SCHEMBL9952518 0.81 CDC7 (0.44) CDC7ROCK2MAP4K4PIM1CDK2
SCHEMBL10194977 0.79 FGFR1 (0.45) FGFR1FLT1CDC7ROCK2MAP4K4
SCHEMBL9952065 0.78 CDC7 (0.46) FGFR1CDC7ROCK2MAP4K4PIM1
SCHEMBL9951810 0.78 FKBP1A (0.47) FGFR1FLT1CDC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2655357-B1 INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS MERCK SERONO SA (CH) 2016-06-22 — — EP disclosed
EP-2655357-B1 INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS MERCK SERONO SA (CH) 2016-06-22 — — EP disclosed
US-9073892-B2 Indazolyl triazol derivatives MERCK SERONO S.A. (CH) 2015-07-07 — — US disclosed
US-9073892-B2 Indazolyl triazol derivatives MERCK SERONO S.A. (CH) 2015-07-07 — — US disclosed
US-9073892-B2 Indazolyl triazol derivatives MERCK SERONO S.A. (CH) 2015-07-07 — — US disclosed
US-20130274241-A1 INDAZOLYL TRIAZOL DERIVATIVES MERCK SERONO S.A. - INTELLECTUAL PROPERTY (CH) 2013-10-17 — — US disclosed
US-20130274241-A1 INDAZOLYL TRIAZOL DERIVATIVES MERCK SERONO S.A. - INTELLECTUAL PROPERTY (CH) 2013-10-17 — — US disclosed
US-20130274241-A1 INDAZOLYL TRIAZOL DERIVATIVES MERCK SERONO S.A. - INTELLECTUAL PROPERTY (CH) 2013-10-17 — — US disclosed
WO-2012084704-A1 INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS MERCK SERONO S.A. (CH) 2012-06-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130274241-A1 INDAZOLYL TRIAZOL DERIVATIVES NFATC1, IL5, CD4 FGFR1 3392/4885FLT1 1926/4885CDC7 1831/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.