SCHEMBL10195282

SCHEMBL10195282

CCc1ccc(Oc2ncc(Cl)cc2[N+](=O)[O-])cc1C1=C(O)C(C)(C)OC(C)(C)C1=O

nearest known ligand 0.34

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.34
PIN1 Q13526 2/20 0.33
KDM4E B2RXH2 1/20 0.32
MEN1 O00255 1/20 0.32
ALDH1A1 P00352 1/20 0.32
POLB P06746 1/20 0.32
GAA P10253 1/20 0.32
KMT2A Q03164 1/20 0.32
PPARG P37231 1/20 0.31
INPPL1 O15357 1/20 0.31
BCHE P06276 1/20 0.31
LIPE Q05469 1/20 0.31
LMNA P02545 2/20 0.30
SMN1; SMN2 Q16637 2/20 0.30
CYP2C9 P11712 1/20 0.30
TSHR P16473 1/20 0.30
APEX1 P27695 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10195136 0.87 MAPK1 (0.47) MAPK1KDM4EPOLBPPARGBCHE
SCHEMBL16181143 0.87 DRD1 (0.40) MAPK1PPARGBCHELIPELMNA
SCHEMBL10195148 0.86 PPARG (0.38) MAPK1PPARGBCHELIPELMNA
SCHEMBL10195376 0.85 PDE7A (0.44) MAPK1KDM4EMEN1ALDH1A1POLB
SCHEMBL10195020 0.84 LMNA (0.33) MAPK1MEN1ALDH1A1POLBGAA
SCHEMBL10195261 0.83 MAPK1 (0.34) MAPK1ALDH1A1BCHELIPELMNA
SCHEMBL10195211 0.82 KDM4E (0.30) MAPK1KDM4EALDH1A1GAA
SCHEMBL10195276 0.81 MAPK1 (0.37) MAPK1BCHELIPELMNASMN1; SMN2
SCHEMBL16180986 0.81 DRD1 (0.40) MAPK1BCHELIPELMNASMN1; SMN2
SCHEMBL10195341 0.81 ALDH1A1 (0.37) KDM4EMEN1ALDH1A1POLBGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140378305-A1 NOVEL HERBICIDES SYNGENTA LIMITED (GB) 2014-12-25 US disclosed
US-8865623-B2 Herbicidally active cyclic diones and derivatives thereof, processes for their preparation, compositions, and method of controlling weeds SYNGENTA LIMITED (GB) 2014-10-21 US disclosed
US-20120021907-A1 NOVEL HERBICIDES SYNGENTA CROP PROTECTION LLC (US) 2012-01-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140378305-A1 NOVEL HERBICIDES DDT, CYP4X1, CYP1B1 MAPK1 2927/4885PIN1 333/4885KDM4E 712/4885
US-20120021907-A1 NOVEL HERBICIDES DDT, CYP4X1, CYP1B1 MAPK1 2263/4885PIN1 189/4885KDM4E 1092/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.