SCHEMBL10196207

SCHEMBL10196207

CCc1ccc(Oc2nc3ccc(Cl)cc3s2)cc1C1=C(O)CCC1=O

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 1/20 0.36
CTSD P07339 1/20 0.35
KMT2A Q03164 1/20 0.35
EPHX2 P34913 4/20 0.35
NPC1 O15118 3/20 0.35
RAB9A P51151 3/20 0.35
DYRK1A Q13627 1/20 0.34
FSCN1 Q16658 1/20 0.34
PPARA Q07869 2/20 0.34
DCLK1 O15075 1/20 0.34
FES P07332 1/20 0.34
PIM1 P11309 1/20 0.34
CDK2 P24941 1/20 0.34
GSK3A P49840 1/20 0.34
GSK3B P49841 1/20 0.34
IRAK1 P51617 1/20 0.34
MAP4K2 Q12851 1/20 0.34
NTRK3 Q16288 1/20 0.34
HIPK4 Q8NE63 1/20 0.34
AURKB Q96GD4 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10196215 0.93 CTSD (0.35) CTSDEPHX2PPARAGAASMN1; SMN2
SCHEMBL10196229 0.90 SMN1; SMN2 (0.41) KMT2ANPC1RAB9ADYRK1ACSNK1D
SCHEMBL13190205 0.88 SMN1; SMN2 (0.37) CTSDKMT2AEPHX2RAB9AKDM4E
SCHEMBL10196205 0.87 CYP1A2 (0.45) CTSDEPHX2SMN1; SMN2LTA4H
SCHEMBL10195491 0.87 SMN1; SMN2 (0.44) PTPN1CTSDKMT2AEPHX2NPC1
SCHEMBL19070658 0.86 EPHX2 (0.34) PTPN1KMT2AEPHX2RAB9AKDM4E
SCHEMBL10196232 0.86 CTSD (0.35) CTSDNPC1RAB9AALDH1A1SMN1; SMN2
SCHEMBL10196227 0.85 KMT2A (0.41) PTPN1KMT2ANPC1RAB9ADYRK1A
SCHEMBL10195516 0.83 LTA4H (0.34) PTPN1CTSDKMT2AEPHX2NPC1
SCHEMBL19070663 0.81 PPARG (0.36) PTPN1CTSDKMT2AEPHX2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2389066-B1 CYCLOPENTADIONE DERIVED HERBICIDES SYNGENTA LTD (GB) 2017-07-05 EP disclosed
US-8895474-B2 Herbicidally active cyclopentanediones and derivatives thereof, and their use in controlling weeds SYNGENTA LIMITED (GB) 2014-11-25 US disclosed
US-8895474-B2 Herbicidally active cyclopentanediones and derivatives thereof, and their use in controlling weeds SYNGENTA LIMITED (GB) 2014-11-25 US disclosed
US-20120021912-A1 NOVEL HERBICIDES SYNGENTA CROP PROTECTION LLC (US) 2012-01-26 US disclosed
US-20120021912-A1 NOVEL HERBICIDES SYNGENTA CROP PROTECTION LLC (US) 2012-01-26 US disclosed
WO-2010102848-A1 CYCLOPENTADIONE DERIVED HERBICIDES SYNGENTA LIMITED (GB) 2010-09-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120021912-A1 NOVEL HERBICIDES DDT, CYP4X1, CYP1B1 PTPN1 374/4885CTSD 3465/4885KMT2A 674/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.