SCHEMBL1019625

SCHEMBL1019625

Cc1cc(Cl)c(C)c(C)c1Cl

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.43
CHRM1 P11229 1/20 0.43
ALOX15 P16050 1/20 0.43
MAOA P21397 1/20 0.43
TBXA2R P21731 1/20 0.43
ADRA1A P35348 1/20 0.43
HTR2B P41595 1/20 0.43
ALDH1A1 P00352 2/20 0.43
GAA P10253 1/20 0.43
MAPT P10636 1/20 0.43
SIRT1 Q96EB6 1/20 0.39
RAPGEF4 Q8WZA2 5/20 0.37
CD44 P16070 1/20 0.36
PDE3B Q13370 1/20 0.32
PDE3A Q14432 1/20 0.32
GRIN2D O15399 1/20 0.30
GRIN3B O60391 1/20 0.30
GRIN1 Q05586 1/20 0.30
GRIN2A Q12879 1/20 0.30
GRIN2B Q13224 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31497683 1.00 CYP3A4 (0.43) CYP3A4CHRM1ALOX15MAOATBXA2R
SCHEMBL9419974 0.82 CYP3A4 (0.43) CYP3A4CHRM1ALOX15MAOATBXA2R
SCHEMBL31465325 0.82 CYP3A4 (0.43) CYP3A4CHRM1ALOX15MAOATBXA2R
SCHEMBL1006177 0.82 CYP3A4 (0.43) CYP3A4CHRM1ALOX15MAOATBXA2R
SCHEMBL28492412 0.80 CYP3A4 (0.42) CYP3A4CHRM1ALOX15MAOATBXA2R
Water SCHEMBL28512050 0.80 CYP3A4 (0.42) CYP3A4CHRM1ALOX15MAOATBXA2R
SCHEMBL906696 0.79 CYP3A4 (0.46) CYP3A4CHRM1ALOX15MAOATBXA2R
SCHEMBL17473830 0.79 CD44 (0.38) CYP3A4CHRM1ALOX15MAOATBXA2R
SCHEMBL25978067 0.79 CYP3A4 (0.50) CYP3A4CHRM1ALOX15MAOATBXA2R
SCHEMBL1003476 0.78 CYP3A4 (0.50) CYP3A4CHRM1ALOX15MAOATBXA2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6831111-B1 New or recycled Polystyrene and copolymers processed to become macroreticular, structure designed to absorb organic solvents and oil molecularly; crosslinked with 1,4-dichloromethyl-2,5-dichloromethyl-2,5- dimethylbenzene INNOVAL MANAGEMENT LIMITED (AN) 2004-12-14 US claimed
EP-1025135-B1 METHOD OF PREPARATION OF PRODUCTS WHICH ABSORB WATER INTRAMOLECULARLY INNOVAL MAN LTD (AN) 2004-09-29 EP claimed
EP-0902795-B1 METHOD AND PRODUCTS TO ABSORB OIL AND ORGANIC SOLVENTS FROM WATER AND FROM SEA INNOVAL MAN LTD (AN) 2002-12-04 EP claimed
US-6476152-B1 Method of preparation of products which absorb water intermolecularly INNOVAL MANAGEMENT, LTD. (NL) 2002-11-05 US claimed
EP-1025135-A1 METHOD OF PREPARATION OF PRODUCTS WHICH ABSORB WATER INTERMOLECULARLY Innoval Management Limited (AN) 2000-08-09 EP claimed
WO-1999021897-A1 METHOD OF PREPARATION OF PRODUCTS WHICH ABSORB WATER INTERMOLECULARLY INNOVAL MANAGEMENT LIMITED (AN) 1999-05-06 WO claimed
JP-2229136-A None JP disclosed
US-20240216355-A1 PHARMACEUTICAL COMPOSITIONS FOR USE IN THE PREVENTION AND TREATMENT OF A DISEASE OR DISORDER CAUSED BY OR ASSOCIATED WITH ONE OR MORE PREMATURE TERMINATION CODONS MONTE ROSA THERAPEUTICS AG (CH) 2024-07-04 US disclosed
US-20240216355-A1 PHARMACEUTICAL COMPOSITIONS FOR USE IN THE PREVENTION AND TREATMENT OF A DISEASE OR DISORDER CAUSED BY OR ASSOCIATED WITH ONE OR MORE PREMATURE TERMINATION CODONS MONTE ROSA THERAPEUTICS AG (CH) 2024-07-04 US disclosed
US-20230132149-A1 ULTRA NARROW BANDGAP NON-FULLERENE-ACCEPTOR BASED ORGANIC ELECTRONICS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2023-04-27 US disclosed
EP-2137228-B1 POLYESTER COMPOSITIONS HAVING IMPROVED HEAT RESISTANCE SABIC INNOVATIVE PLASTICS IP (NL) 2011-01-12 EP disclosed
US-20080242783-A1 POLYESTER COMPOSITIONS HAVING IMPROVED HEAT RESISTANCE CITIBANK, N.A., AS COLLATERAL AGENT 2008-10-02 US disclosed
US-20080242784-A1 POLYESTER COMPOSITIONS HAVING IMPROVED HEAT RESISTANCE CITIBANK, N.A., AS COLLATERAL AGENT 2008-10-02 US disclosed
US-4880901-A DICHLOROAROMATICS WITH SODIUM SULFIDE AND ONE TRIHALOAROMATIC, INJECTION MOLDING PHILLIPS PETROLEUM COMPANY (US) 1989-11-14 US disclosed
EP-0318836-A2 Poly(arylene sulfide) process compositions and articles of manufacture PHILLIPS PETROLEUM COMPANY (US) 1989-06-07 EP disclosed
EP-0100551-B1 ARYLENE SULFIDE TERPOLYMERS AND PROCESSES FOR MAKING THEM PHILLIPS PETROLEUM COMPANY (US) 1987-07-15 EP disclosed
EP-0176292-A2 Aromatic polymers NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) 1986-04-02 EP disclosed
EP-0100551-A2 Arylene sulfide terpolymers and processes for making them PHILLIPS PETROLEUM COMPANY (US) 1984-02-15 EP disclosed
US-4059610-A Process for preparing isocyanic acid derivatives KAO SOAP CO., LTD. (JA) 1977-11-22 US disclosed
US-4056547-A FROM AN ALKALI METAL OR AMMONIUM CYANATE AND A BENZYL CHLORIDE, CATALYST KAO SOAP CO., LTD. (JA) 1977-11-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240216355-A1 PHARMACEUTICAL COMPOSITIONS FOR USE IN THE PREVENTION AND TREATMENT OF A DISEASE OR DISORDER CAUSED BY OR ASSOCIATED WITH ONE OR MORE PREMATURE TERMINATION CODONS UPF1, NSUN2, RTF2 CYP3A4 3128/4885CHRM1 901/4885ALOX15 2992/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.