Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 11/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.48 |
| ▸ | SOAT2 | O75908 | 2/20 | 0.43 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10197900 | 0.87 | DGAT1 (0.70) | DGAT1SOAT2SOAT1 | |
| SCHEMBL410033 | 0.87 | DGAT1 (0.70) | DGAT1SOAT2SOAT1 | |
| SCHEMBL410032 | 0.87 | DGAT1 (0.70) | DGAT1SOAT2SOAT1 | |
| SCHEMBL13190414 | 0.86 | PDGFRB (0.51) | DGAT1PDGFRBPDGFRANPC1RAB9A | |
| SCHEMBL10197485 | 0.71 | DGAT1 (0.66) | DGAT1SOAT2SOAT1 | |
| SCHEMBL11035816 | 0.69 | ESR2 (0.47) | DGAT1MEN1NPC1ALDH1A1RAB9A | |
| SCHEMBL11035814 | 0.69 | ESR2 (0.47) | DGAT1MEN1NPC1ALDH1A1RAB9A | |
| SCHEMBL3915443 | 0.69 | PDGFRB (0.76) | PDGFRBPDGFRAMEN1NPC1ALDH1A1 | |
| SCHEMBL10341907 | 0.69 | HDAC4 (0.44) | DGAT1SOAT1MEN1NPC1ALDH1A1 | |
| SCHEMBL10743452 | 0.69 | HDAC4 (0.44) | DGAT1SOAT1MEN1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120022057-A1 | BICYCLIC COMPOUNDS AS INHIBITORS OF DIACYGLYCEROL ACYLTRANSFERASE | SCHERING CORPORATION (US) | 2012-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022057-A1 | BICYCLIC COMPOUNDS AS INHIBITORS OF DIACYGLYCEROL ACYLTRANSFERASE | DGAT2, DGAT1, LCAT | DGAT1 2/4885PDGFRB 3777/4885PDGFRA 3456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.