Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.69 |
| ▸ | MTOR | P42345 | 12/20 | 0.69 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.47 |
| ▸ | STK4 | Q13043 | 1/20 | 0.47 |
| ▸ | STK3 | Q13188 | 1/20 | 0.47 |
| ▸ | AKT1 | P31749 | 1/20 | 0.47 |
| ▸ | MAP3K6 | O95382 | 3/20 | 0.46 |
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.46 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.44 |
| ▸ | CKS1B | P61024 | 1/20 | 0.43 |
| ▸ | SKP1 | P63208 | 1/20 | 0.43 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12137612 | 0.88 | PIK3CA (0.57) | PIK3CAMTORLRRK2STK4STK3 | |
| SCHEMBL10198433 | 0.85 | PIK3CA (0.70) | PIK3CAMTORCKS1BSKP1SKP2 | |
| SCHEMBL6897445 | 0.82 | PIK3CA (1.00) | PIK3CAMTOR | |
| SCHEMBL6896339 | 0.81 | PIK3CA (0.55) | PIK3CAMTOR | |
| SCHEMBL6896211 | 0.81 | PIK3CA (0.54) | PIK3CAMTOR | |
| SCHEMBL10195811 | 0.79 | PIK3CA (0.66) | PIK3CAMTORAKT1 | |
| SCHEMBL10195998 | 0.79 | PIK3CA (0.69) | PIK3CAMTOR | |
| SCHEMBL10196541 | 0.78 | PIK3CA (0.70) | PIK3CAMTOR | |
| SCHEMBL10196526 | 0.78 | MTOR (0.68) | PIK3CAMTOR | |
| SCHEMBL12137339 | 0.78 | PIK3CA (0.46) | PIK3CAMTORMAP3K6MAP3K5PAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028958-A1 | 5-ALKYNYL-PYRIMIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028958-A1 | 5-ALKYNYL-PYRIMIDINES | MKI67, CCNA1, CCNT1 | PIK3CA 1435/4885MTOR 1358/4885LRRK2 1388/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.