Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 18/20 | 0.70 |
| ▸ | MTOR | P42345 | 18/20 | 0.70 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.51 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.51 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.51 |
| ▸ | CKS1B | P61024 | 1/20 | 0.46 |
| ▸ | SKP1 | P63208 | 1/20 | 0.46 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6895765 | 0.87 | PIK3CA (0.55) | PIK3CAMTORSIRT2SIRT1SIRT3 | |
| SCHEMBL6896339 | 0.85 | PIK3CA (0.55) | PIK3CAMTOR | |
| SCHEMBL10197828 | 0.85 | PIK3CA (0.69) | PIK3CAMTORCKS1BSKP1SKP2 | |
| SCHEMBL6896211 | 0.84 | PIK3CA (0.54) | PIK3CAMTOR | |
| SCHEMBL6894094 | 0.83 | PIK3CA (1.00) | PIK3CAMTOR | |
| SCHEMBL10196526 | 0.82 | MTOR (0.68) | PIK3CAMTOR | |
| SCHEMBL10196541 | 0.82 | PIK3CA (0.70) | PIK3CAMTOR | |
| SCHEMBL10195779 | 0.81 | PIK3CA (0.68) | PIK3CAMTOR | |
| SCHEMBL10195811 | 0.79 | PIK3CA (0.66) | PIK3CAMTOR | |
| SCHEMBL12137763 | 0.78 | PIK3CA (0.53) | PIK3CAMTORCKS1BSKP1SKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028958-A1 | 5-ALKYNYL-PYRIMIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028958-A1 | 5-ALKYNYL-PYRIMIDINES | MKI67, CCNA1, CCNT1 | PIK3CA 1435/4885MTOR 1358/4885SIRT2 3138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.