Sugi Predict

Sugi Predict / Compounds / SCHEMBL10198745

SCHEMBL10198745

SCHEMBL10198745

CC[C@H](NC(=O)OC(C)(C)C)C(=O)N(C(=O)c1c(F)cccc1N=O)c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ CTSK P43235 10/20 0.41
▸ CTSS P25774 7/20 0.41
▸ PTPN1 P18031 1/20 0.37
▸ JAK3 P52333 1/20 0.37
▸ BTK Q06187 1/20 0.37
▸ CTSB P07858 2/20 0.36
▸ CTSL P07711 1/20 0.36
▸ PPARA Q07869 2/20 0.36
▸ PPARG P37231 1/20 0.36
▸ SYK P43405 1/20 0.36
▸ ATM Q13315 1/20 0.35
▸ ACE P12821 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19499812 0.84 CTSK (0.40) CTSKCTSSPTPN1CTSBCTSL
SCHEMBL10163616 0.84 CTSK (0.40) CTSKCTSSPTPN1CTSBCTSL
SCHEMBL16133575 0.75 CTSS (0.39) CTSKCTSSPTPN1JAK3BTK
SCHEMBL21272242 0.73 PPARA (0.46) CTSKCTSSJAK3BTKCTSB
SCHEMBL9813178 0.72 CTSS (0.51) CTSKCTSSPTPN1CTSBCTSL
SCHEMBL18121553 0.71 CTSS (0.38) CTSKCTSS
SCHEMBL17892689 0.70 SMN1; SMN2 (0.42) —
SCHEMBL16858275 0.69 CTSS (0.47) CTSKCTSSCTSBCTSLATM
SCHEMBL14085940 0.68 CTSS (0.52) CTSKCTSSCTSBCTSLPPARA
SCHEMBL20702099 0.67 CTSS (0.46) CTSKCTSSPTPN1CTSBCTSL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8207153-B2 Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta ICOS CORPORATION (US) 2012-06-26 — — US disclosed
US-20120015964-A1 QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA ICOS CORPORATION (US) 2012-01-19 — — US disclosed
US-7932260-B2 Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta ICOS CORPORATION (US) 2011-04-26 — — US disclosed
US-20100256168-A1 QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA ICOS CORPORATION 2010-10-07 — — US disclosed
US-20100256167-A1 QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA ICOS CORPORATION 2010-10-07 — — US disclosed
US-20080275067-A1 Quinazolinones as Inhibitors of Human Phosphatidylinositol 3-Kinase Delta ICOS CORPORATION (US) 2008-11-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100256167-A1 QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA PIK3CD, PIK3CA, PI4KA CTSK 511/4885CTSS 1673/4885PTPN1 489/4885
US-20120015964-A1 QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA PIK3CD, PIK3CA, PI4KA CTSK 511/4885CTSS 1673/4885PTPN1 489/4885
US-20100256168-A1 QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA PIK3CD, PIK3CA, PI4KA CTSK 511/4885CTSS 1673/4885PTPN1 489/4885
US-20080275067-A1 Quinazolinones as Inhibitors of Human Phosphatidylinositol 3-Kinase Delta PIK3CD, PIK3CA, PI4KA CTSK 511/4885CTSS 1673/4885PTPN1 489/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.