Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 7/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KIF11 | P52732 | 8/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8404188 | 0.96 | TP53 (0.51) | TP53MAPTSMN1; SMN2KIF11LMNA | |
| SCHEMBL11917335 | 0.96 | TP53 (0.51) | TP53MAPTSMN1; SMN2KIF11LMNA | |
| SCHEMBL13049404 | 0.95 | LMNA (0.51) | TP53MAPTSMN1; SMN2KIF11LMNA | |
| SCHEMBL11912547 | 0.95 | LMNA (0.51) | TP53MAPTSMN1; SMN2KIF11LMNA | |
| SCHEMBL8403607 | 0.95 | SIRT1 (0.52) | TP53MAPTSMN1; SMN2KIF11LMNA | |
| SCHEMBL13647309 | 0.94 | SIRT1 (0.51) | TP53MAPTSMN1; SMN2KIF11LMNA | |
| SCHEMBL763497 | 0.94 | SIRT1 (0.51) | TP53MAPTSMN1; SMN2KIF11LMNA | |
| SCHEMBL8403083 | 0.93 | TP53 (0.53) | TP53MAPTSMN1; SMN2KIF11LMNA | |
| SCHEMBL11912532 | 0.93 | TP53 (0.48) | TP53MAPTSMN1; SMN2KIF11LMNA | |
| SCHEMBL763760 | 0.93 | TP53 (0.49) | TP53MAPTSMN1; SMN2KIF11LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2431369-A2 | Carboline derivatives useful in the inhibition of angiogenesis | PTC Therapeutics, Inc. (US) | 2012-03-21 | — | — | EP | disclosed |
| WO-2005089764-A9 | CARBOLINE DERIVATIVES USEFUL IN THE INHIBITION OF ANGIOGENESIS | PTC THERAPEUTICS INC (US) | 2007-09-13 | — | — | WO | disclosed |