Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 5/20 | 0.51 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | LGMN | Q99538 | 1/20 | 0.32 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL480206 | 0.80 | ALOX5AP (0.64) | ALOX5APNR1I2CYP2C9LGMN | |
| SCHEMBL10197150 | 0.78 | ALOX5AP (0.70) | ALOX5APCYP11B1CYP11B2CYP2C9 | |
| SCHEMBL14397148 | 0.77 | ALOX5AP (0.43) | ALOX5AP | |
| SCHEMBL14396912 | 0.77 | ALOX5AP (0.43) | ALOX5AP | |
| SCHEMBL31226448 | 0.73 | HSD17B1 (0.56) | HSD17B1CYP11B1CYP11B2HDAC1LOXL2 | |
| SCHEMBL13262244 | 0.73 | ALOX5AP (0.47) | ALOX5AP | |
| SCHEMBL14397218 | 0.71 | ALOX5AP (0.55) | ALOX5APNR1I2CYP2C9 | |
| SCHEMBL480222 | 0.69 | ALOX5AP (0.67) | ALOX5APCYP11B1CYP11B2CYP2C9HDAC1 | |
| SCHEMBL480237 | 0.69 | ALOX5AP (0.64) | ALOX5APCYP11B1CYP11B2CYP2C9HDAC1 | |
| SCHEMBL10199332 | 0.69 | ALOX5AP (0.47) | ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2064204-B1 | INHIBITORS OF 5 -LIPOXYGENASE ACTIVATING PROTEIN ( FLAP) | MERCK SHARP & DOHME (US) | 2012-02-01 | — | — | EP | disclosed |