Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | ACACA | Q13085 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | TACR3 | P29371 | 4/20 | 0.52 |
| ▸ | NQO2 | P16083 | 1/20 | 0.50 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13336764 | 0.90 | KDM4E (0.68) | KDM4ESMN1; SMN2MEN1KMT2APLA2G2A | |
| SCHEMBL14040372 | 0.85 | KDM4E (0.63) | KDM4ESMN1; SMN2MEN1KMT2APLA2G2A | |
| SCHEMBL30064616 | 0.82 | KDM4E (0.75) | KDM4ESMN1; SMN2MEN1KMT2APLA2G2A | |
| SCHEMBL28350370 | 0.82 | KDM4E (0.75) | KDM4ESMN1; SMN2MEN1KMT2APLA2G2A | |
| SCHEMBL10263305 | 0.81 | KDM4E (0.73) | KDM4ESMN1; SMN2MEN1KMT2APLA2G2A | |
| SCHEMBL13757621 | 0.81 | SMN1; SMN2 (1.00) | KDM4ESMN1; SMN2MEN1KMT2APLA2G2A | |
| SCHEMBL6534504 | 0.80 | KDM4E (0.56) | KDM4ESMN1; SMN2MEN1KMT2APLA2G2A | |
| SCHEMBL12768139 | 0.80 | ACHE (0.56) | KDM4ESMN1; SMN2ALDH1A1ACACALMNA | |
| SCHEMBL6498067 | 0.79 | KDM4E (0.71) | KDM4ESMN1; SMN2MEN1KMT2APLA2G2A | |
| SCHEMBL12285330 | 0.79 | KDM4E (0.71) | KDM4ESMN1; SMN2MEN1KMT2APLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110687-B2 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-02-07 | — | — | US | disclosed |
| US-20080064729-A1 | Phenethylamide derivatives with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-03-13 | — | — | US | disclosed |
| US-20070149533-A1 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064729-A1 | Phenethylamide derivatives with kinase inhibitory activity | MAP4K5, MAP3K5, MAP4K2 | KDM4E 99/4885SMN1; SMN2 3127/4885MEN1 1953/4885 |
| US-20070149533-A1 | Bicyclic compounds with kinase inhibitory activity | MAP3K20, MAP3K1, MAP3K5 | KDM4E 1104/4885SMN1; SMN2 3423/4885MEN1 2916/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.