Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | ACACA | Q13085 | 1/20 | 0.52 |
| ▸ | CALCRL | Q16602 | 2/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.50 |
| ▸ | TACR3 | P29371 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6534504 | 0.87 | KDM4E (0.56) | KDM4ESMN1; SMN2MEN1KMT2APLA2G2A | |
| SCHEMBL10199562 | 0.85 | KDM4E (0.68) | KDM4ESMN1; SMN2MEN1KMT2APLA2G2A | |
| SCHEMBL6498067 | 0.79 | KDM4E (0.71) | KDM4ESMN1; SMN2MEN1KMT2APLA2G2A | |
| SCHEMBL10610678 | 0.79 | KDM4E (0.71) | KDM4ESMN1; SMN2MEN1KMT2APLA2G2A | |
| SCHEMBL30064616 | 0.79 | KDM4E (0.75) | KDM4ESMN1; SMN2MEN1KMT2APLA2G2A | |
| SCHEMBL28350370 | 0.79 | KDM4E (0.75) | KDM4ESMN1; SMN2MEN1KMT2APLA2G2A | |
| SCHEMBL13757621 | 0.77 | SMN1; SMN2 (1.00) | KDM4ESMN1; SMN2MEN1KMT2APLA2G2A | |
| SCHEMBL10263305 | 0.77 | KDM4E (0.73) | KDM4ESMN1; SMN2MEN1KMT2APLA2G2A | |
| SCHEMBL14040263 | 0.76 | PLA2G2A (0.77) | KDM4ESMN1; SMN2MEN1KMT2APLA2G2A | |
| SCHEMBL12285330 | 0.76 | KDM4E (0.71) | KDM4ESMN1; SMN2MEN1KMT2APLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008116671-A1 | 2,3,4,9-TETRAHYDRO-1H-CARBAZOLES | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-10-02 | — | — | WO | disclosed |
| EP-1975159-A1 | 2,3,4,9-Tetrahydro-1H-carbazoles | Bayer Schering Pharma Aktiengesellschaft (DE) | 2008-10-01 | — | — | EP | disclosed |