Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 12/20 | 0.48 |
| ▸ | GABRB2 | P47870 | 12/20 | 0.48 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1023792 | 0.92 | GABRA1 (0.51) | GABRA1GABRB2GABRB1GABRA3KDM4E | |
| SCHEMBL1082077 | 0.90 | GABRA1 (0.49) | GABRA1GABRB2GABRB1GABRA3ADORA2A | |
| SCHEMBL1023774 | 0.89 | GABRA1 (0.45) | GABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL1022414 | 0.89 | GABRA1 (0.48) | GABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL1021755 | 0.88 | GABRA1 (0.46) | GABRA1GABRB2GABRB1GABRA3KDM4E | |
| SCHEMBL1023670 | 0.88 | GABRA1 (0.47) | GABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL1082654 | 0.88 | GABRA1 (0.45) | GABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL1022302 | 0.80 | GABRA1 (0.68) | GABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL1022218 | 0.79 | GABRA1 (0.54) | GABRA1GABRB2GABRB1GABRA3KDM4E | |
| SCHEMBL1020536 | 0.78 | LMNA (0.48) | GABRA1GABRB2GABRB1GABRA3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954274-B8 | SUBSTITUTED QUINOLONES AND METHODS OF USE | CHEMOCENTRYX INC (US) | 2011-01-12 | — | — | EP | disclosed |
| EP-1954274-A4 | SUBSTITUTED QUINOLONES AND METHODS OF USE | CHEMOCENTRYX INC (US) | 2009-01-07 | — | — | EP | disclosed |
| EP-1954274-A2 | SUBSTITUTED QUINOLONES AND METHODS OF USE | ChemoCentryx Inc (US) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007059108-A2 | SUBSTITUTED QUINOLONES AND METHODS OF USE | CHEMOCENTRYX, INC. (US) | 2007-05-24 | — | — | WO | disclosed |