Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.39 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.39 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 3/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | MMP1 | P03956 | 4/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | MMP7 | P09237 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1021775 | 0.90 | LTA4H (0.42) | LTA4HESR1ESR2ALDH1A1KCNH2 | |
| SCHEMBL1021151 | 0.89 | MMP1 (0.41) | LTA4HESR1ESR2KCNH2MMP1 | |
| SCHEMBL3536025 | 0.88 | CACNA1F (0.41) | LTA4HCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL5175084 | 0.88 | ESR1 (0.42) | LTA4HESR1ESR2ALDH1A1LMNA | |
| SCHEMBL1021774 | 0.84 | LTA4H (0.43) | LTA4HESR1ESR2ALDH1A1KCNH2 | |
| SCHEMBL1021525 | 0.84 | MMP1 (0.40) | ALDH1A1LMNAMMP1MMP3MMP7 | |
| SCHEMBL1022044 | 0.83 | MMP1 (0.46) | LTA4HKCNH2MMP1MMP3MMP7 | |
| SCHEMBL1020684 | 0.78 | ESR1 (0.44) | LTA4HESR1ESR2KCNH2MMP1 | |
| SCHEMBL1020938 | 0.78 | MMP1 (0.43) | LTA4HESR1ESR2KCNH2MMP1 | |
| SCHEMBL1021305 | 0.77 | MMP1 (0.43) | ALDH1A1LMNAMMP1MMP3MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869001-B1 | SUBSTITUTED TETRAHYDROISOCHINOLINES AS MMP INHIBITORS, RELATED PRODUCTION METHOD AND USE AS MEDICINE | SANOFI AVENTIS (FR) | 2011-01-12 | — | — | EP | disclosed |