Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 18/20 | 0.62 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL894254 | 0.95 | TRPA1 (0.68) | TRPA1ATM | |
| SCHEMBL891306 | 0.92 | TRPA1 (0.64) | TRPA1ATMTSHR | |
| SCHEMBL893279 | 0.89 | TRPA1 (0.62) | TRPA1ATM | |
| SCHEMBL893906 | 0.89 | TRPA1 (0.66) | TRPA1ATM | |
| SCHEMBL893512 | 0.88 | TRPA1 (0.65) | TRPA1ATM | |
| SCHEMBL893499 | 0.88 | TRPA1 (0.65) | TRPA1ATM | |
| SCHEMBL10201395 | 0.88 | TRPA1 (0.65) | TRPA1ATM | |
| SCHEMBL893356 | 0.88 | TRPA1 (0.78) | TRPA1ATM | |
| SCHEMBL893828 | 0.87 | TRPA1 (0.62) | TRPA1ATMTSHR | |
| SCHEMBL892949 | 0.86 | TRPA1 (0.61) | TRPA1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120083474-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2012-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120083474-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | TRPA1, TRPV1, TRPV2 | TRPA1 1/4885ATM 2689/4885TSHR 2952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.