Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 9/20 | 0.49 |
| ▸ | ITGB6 | P18564 | 9/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.49 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.49 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.49 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.49 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.49 |
| ▸ | LIMK2 | P53671 | 9/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 8/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.35 |
| ▸ | PRKACA | P17612 | 5/20 | 0.35 |
| ▸ | PRKACG | P22612 | 5/20 | 0.35 |
| ▸ | PRKACB | P22694 | 5/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13003788 | 1.00 | ITGAV (0.49) | ITGAVITGB6ITGB3ITGB1ITGA5 | |
| SCHEMBL328187 | 0.91 | ITGAV (0.48) | ITGAVITGB6ITGB3ITGB1ITGA5 | |
| SCHEMBL328007 | 0.91 | ITGAV (0.48) | ITGAVITGB6ITGB3ITGB1ITGA5 | |
| SCHEMBL328202 | 0.89 | ITGAV (0.51) | ITGAVITGB6ITGB3ITGB1ITGA5 | |
| SCHEMBL277171 | 0.86 | ITGB3 (0.47) | ITGAVITGB6ITGB3ITGB1ITGA5 | |
| SCHEMBL327985 | 0.86 | ITGAV (0.52) | ITGAVITGB6ITGB3ITGB1ITGA5 | |
| SCHEMBL328079 | 0.84 | ITGAV (0.43) | ITGAVITGB6ITGB3ITGB1ITGA5 | |
| SCHEMBL328084 | 0.84 | ITGAV (0.43) | ITGAVITGB6ITGB3ITGB1ITGA5 | |
| SCHEMBL275846 | 0.84 | ITGAV (0.54) | ITGAVITGB6ITGB3ITGB1ITGA5 | |
| SCHEMBL13003793 | 0.84 | ITGAV (0.50) | ITGAVITGB6ITGB3ITGB1ITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120115883-A1 | PYRIMIDINE DERIVATIVES WHICH ARE ANTAGONISTS OF THE VITRONECTIN RECEPTOR | GALAPAGOS SAS | 2012-05-10 | — | — | US | disclosed |
| US-8133896-B2 | Pyrimidine derivatives which are antagonist of the vitronectin receptor | GALAPAGOS NV (BE) | 2012-03-13 | — | — | US | disclosed |
| US-20110039867-A1 | PYRIMIDINE DERIVATIVES WHICH ARE ANTAGONIST OF THE VITRONECTIN RECEPTOR | GALAPAGOS SAS | 2011-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039867-A1 | PYRIMIDINE DERIVATIVES WHICH ARE ANTAGONIST OF THE VITRONECTIN RECEPTOR | P2RY1, P2RY2, P2RX5 | ITGAV 492/4885ITGB6 376/4885ITGB3 273/4885 |
| US-20120115883-A1 | PYRIMIDINE DERIVATIVES WHICH ARE ANTAGONISTS OF THE VITRONECTIN RECEPTOR | P2RY1, P2RY2, P2RX5 | ITGAV 455/4885ITGB6 335/4885ITGB3 248/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.