Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.39 |
| ▸ | INSR | P06213 | 3/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.38 |
| ▸ | BTK | Q06187 | 3/20 | 0.38 |
| ▸ | JAK3 | P52333 | 3/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | TXK | P42681 | 1/20 | 0.36 |
| ▸ | BLK | P51451 | 1/20 | 0.36 |
| ▸ | ITK | Q08881 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10205190 | 0.92 | EGFR (0.51) | EGFRALKINSRIGF1RFLT4 | |
| SCHEMBL10205209 | 0.91 | ALK (0.47) | EGFRALKINSRIGF1RFLT4 | |
| SCHEMBL10205181 | 0.91 | EGFR (0.45) | EGFRALKINSRIGF1RTNK2 | |
| SCHEMBL10207086 | 0.90 | EGFR (0.41) | EGFRALKINSRIGF1RFLT4 | |
| SCHEMBL14331739 | 0.90 | EGFR (0.46) | EGFRALKINSRIGF1RFLT4 | |
| SCHEMBL10206626 | 0.90 | STK17A (0.42) | EGFRALKFLT4PTK2TNK2 | |
| SCHEMBL16255604 | 0.89 | FLT4 (0.41) | EGFRALKINSRIGF1RFLT4 | |
| SCHEMBL14331737 | 0.88 | EGFR (0.40) | EGFRALKINSRIGF1RFLT4 | |
| SCHEMBL10205180 | 0.88 | EGFR (0.41) | EGFRALKINSRIGF1RFLT4 | |
| SCHEMBL10205935 | 0.88 | ALK (0.45) | EGFRALKINSRFLT4PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085126-A1 | OXINDOLOPYRIMIDINE AS IGF1R RECEPTOR INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-28 | — | — | WO | disclosed |