Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 9/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 2/20 | 0.55 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | PTPRB | P23467 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6090805 | 0.85 | HPGD (0.74) | HPGDLMNAMAPTALDH1A1KDM4E | |
| SCHEMBL475759 | 0.82 | HPGD (0.70) | HPGDLMNAMAPTALDH1A1KDM4E | |
| SCHEMBL63833 | 0.81 | HPGD (0.70) | HPGDLMNAMAPTALDH1A1KDM4E | |
| SCHEMBL6526759 | 0.81 | HPGD (0.69) | HPGDLMNAMAPTALDH1A1RECQL | |
| SCHEMBL1017480 | 0.81 | HPGD (0.72) | HPGDLMNAMAPTALDH1A1KMT2A | |
| SCHEMBL9514803 | 0.81 | HPGD (0.69) | HPGDLMNAMAPTALDH1A1MEN1 | |
| SCHEMBL18873305 | 0.81 | HPGD (0.69) | HPGDLMNAMAPTALDH1A1KDM4E | |
| SCHEMBL4187307 | 0.80 | POLB (0.72) | HPGDLMNAMAPTALDH1A1KDM4E | |
| SCHEMBL457811 | 0.80 | HPGD (0.67) | HPGDLMNAMAPTALDH1A1KDM4E | |
| SCHEMBL7861945 | 0.80 | HPGD (0.67) | HPGDLMNAMAPTALDH1A1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240116872-A1 | PYRIDYL INHIBITORS FOR HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2024-04-11 | — | — | US | disclosed |
| US-20230265054-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2023-08-24 | — | — | US | disclosed |
| EP-3661935-B1 | SUBSTITUTED PYRAZOLOPYRIMIDINES USEFUL AS KINASES INHIBITORS | TELIGENE LTD (CN) | 2022-10-12 | — | — | EP | disclosed |
| US-11344553-B2 | Substituted pyrazolopyrimidines useful as kinases inhibitors | TELIGENE LTD. (CN) | 2022-05-31 | — | — | US | disclosed |
| US-11344553-B2 | Substituted pyrazolopyrimidines useful as kinases inhibitors | TELIGENE LTD. (CN) | 2022-05-31 | — | — | US | disclosed |
| CN-111542522-B | Substituted pyrazolopyrimidines useful as kinase inhibitors | 苏州韬略生物科技有限公司 | 2021-10-15 | — | — | CN | disclosed |
| US-20210315899-A1 | SUBSTITUTED PYRAZOLOPYRIMIDINES USEFUL AS KINASES INHIBITORS | TELIGENE LTD. (CN) | 2021-10-14 | — | — | US | disclosed |
| US-20210315899-A1 | SUBSTITUTED PYRAZOLOPYRIMIDINES USEFUL AS KINASES INHIBITORS | TELIGENE LTD. (CN) | 2021-10-14 | — | — | US | disclosed |
| US-20210070707-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2021-03-11 | — | — | US | disclosed |
| CN-111542522-A | Substituted pyrazolopyrimidines useful as kinase inhibitors | 苏州韬略生物科技有限公司 | 2020-08-14 | — | — | CN | disclosed |
| US-20120094980-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GUNZNER JANET L (US) | 2012-04-19 | — | — | US | disclosed |
| EP-1789390-B1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH INC (US) | 2011-11-09 | — | — | EP | disclosed |
| US-20110092461-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | CURIS ROYALTY LLC | 2011-04-21 | — | — | US | disclosed |
| US-7888364-B2 | Pyridyl inhibitors of hedgehog signalling | CURIS, INC. (US) | 2011-02-15 | — | — | US | disclosed |
| EP-2271642-A2 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | Genentech, Inc. (US) | 2011-01-12 | — | — | EP | disclosed |
| US-20090281089-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2009-11-12 | — | — | US | disclosed |
| WO-2009126863-A2 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2009-10-15 | — | — | WO | disclosed |
| EP-1789390-A2 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | Genentech, Inc. (US) | 2007-05-30 | — | — | EP | disclosed |
| US-20060063779-A1 | Pyridyl inhibitors of hedgehog signalling | CURIS ROYALTY LLC | 2006-03-23 | — | — | US | disclosed |
| WO-2006028958-A2 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2006-03-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210315899-A1 | SUBSTITUTED PYRAZOLOPYRIMIDINES USEFUL AS KINASES INHIBITORS | MAP3K20, MAP3K6, MAP3K8 | HPGD 2114/4885LMNA 3887/4885MAPT 1437/4885 |
| US-20230265054-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | SHH, GLI1, SMO | HPGD 2728/4885LMNA 3716/4885MAPT 3822/4885 |
| US-20240116872-A1 | PYRIDYL INHIBITORS FOR HEDGEHOG SIGNALLING | SHH, GLI1, SMO | HPGD 2664/4885LMNA 3718/4885MAPT 3696/4885 |
| US-20210070707-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | SHH, GLI1, SMO | HPGD 2728/4885LMNA 3716/4885MAPT 3822/4885 |
| US-20090281089-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | SHH, GLI1, SMO | HPGD 2728/4885LMNA 3716/4885MAPT 3822/4885 |
| US-20120094980-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | SHH, GLI1, SMO | HPGD 2728/4885LMNA 3716/4885MAPT 3822/4885 |
| US-20060063779-A1 | Pyridyl inhibitors of hedgehog signalling | SHH, GLI1, SMO | HPGD 2728/4885LMNA 3716/4885MAPT 3822/4885 |
| US-11344553-B2 | Substituted pyrazolopyrimidines useful as kinases inhibitors | MAP3K20, PRKDC, MAP3K6 | HPGD 2080/4885LMNA 3778/4885MAPT 1533/4885 |
| US-20110092461-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | SHH, GLI1, SMO | HPGD 2728/4885LMNA 3716/4885MAPT 3822/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.