Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.74 |
| ▸ | THRA | P10827 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | CASP1 | P29466 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | AR | P10275 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | PTPRB | P23467 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1020558 | 0.85 | HPGD (1.00) | HPGDLMNASMN1; SMN2RECQLCA1 | |
| SCHEMBL8231736 | 0.84 | THRA (0.59) | HPGDTHRALMNAARSMN1; SMN2 | |
| SCHEMBL9324564 | 0.83 | THRA (0.58) | HPGDTHRALMNAARSMN1; SMN2 | |
| SCHEMBL9324567 | 0.83 | THRA (0.58) | HPGDTHRANPC1RAB9ALMNA | |
| SCHEMBL9491401 | 0.83 | THRA (0.58) | HPGDTHRALMNAARSMN1; SMN2 | |
| SCHEMBL11709119 | 0.81 | HPGD (0.75) | HPGDTHRARAB9ALMNAAR | |
| SCHEMBL7404753 | 0.81 | THRA (0.62) | HPGDTHRALMNAARSMN1; SMN2 | |
| SCHEMBL16051464 | 0.80 | THRA (0.65) | HPGDTHRALMNAARSMN1; SMN2 | |
| SCHEMBL5293554 | 0.79 | HPGD (0.59) | HPGDTHRALMNAARSMN1; SMN2 | |
| SCHEMBL13064478 | 0.79 | HPGD (0.80) | HPGDNPC1RAB9ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006064286-A1 | CATHEPSIN S INHIBITORS | MEDIVIR UK LTD (GB) | 2006-06-22 | — | — | WO | disclosed |
| WO-2006064286-A1 | CATHEPSIN S INHIBITORS | MEDIVIR UK LTD (GB) | 2006-06-22 | — | — | WO | disclosed |