Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 8/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 11/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.43 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.43 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.43 |
| ▸ | TTK | P33981 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14331596 | 0.93 | PTK2 (0.53) | PTK2LRRK2JAK3JAK2NTRK1 | |
| SCHEMBL10205540 | 0.83 | PTK2 (0.55) | PTK2LRRK2TTK | |
| SCHEMBL14331650 | 0.82 | PTK2 (0.48) | PTK2LRRK2JAK3PTK2B | |
| SCHEMBL10205852 | 0.80 | PTK2 (0.50) | PTK2LRRK2JAK3 | |
| SCHEMBL380932 | 0.79 | PTK2 (0.52) | PTK2LRRK2TTK | |
| SCHEMBL16995419 | 0.78 | PTK2 (0.53) | PTK2LRRK2TTK | |
| SCHEMBL10206593 | 0.78 | ALK (0.57) | PTK2 | |
| SCHEMBL16255593 | 0.77 | PTK2 (0.53) | PTK2LRRK2JAK3JAK2NTRK1 | |
| SCHEMBL10205851 | 0.77 | PTK2 (0.48) | PTK2LRRK2JAK3PTK2B | |
| SCHEMBL14331745 | 0.77 | LRRK2 (0.69) | LRRK2TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085126-A1 | OXINDOLOPYRIMIDINE AS IGF1R RECEPTOR INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-28 | — | — | WO | disclosed |