Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SUV39H2 | Q9H5I1 | 4/20 | 0.39 |
| ▸ | DPP4 | P27487 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 2/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13849340 | 0.76 | DPP4 (0.49) | SUV39H2DPP4 | |
| SCHEMBL1911870 | 0.76 | DPP4 (0.49) | SUV39H2DPP4 | |
| SCHEMBL1911858 | 0.76 | ALDH1A1 (0.46) | DPP4ALDH1A1 | |
| SCHEMBL1911887 | 0.76 | DPP4 (0.47) | SUV39H2DPP4SMN1; SMN2CRHBPCRHR2 | |
| SCHEMBL18640030 | 0.75 | SUV39H2 (0.49) | SUV39H2DPP4SMN1; SMN2NR1H4CRHBP | |
| SCHEMBL17059586 | 0.74 | DPP4 (0.43) | DPP4TSHRTDP1ALDH1A1GAA | |
| SCHEMBL26484586 | 0.72 | EGFR (0.40) | DPP4ALDH1A1MAPT | |
| SCHEMBL10206172 | 0.71 | ACVR1 (0.43) | SUV39H2DPP4TSHRTDP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL17870560 | 0.71 | ALDH1A1 (0.46) | DPP4SMN1; SMN2NR1H4CRHBPCRHR2 | |
| SCHEMBL8915331 | 0.71 | FFAR4 (0.52) | NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660458-B1 | 2, 4-PYRIMIDINEDIAMINES USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES, INFLAMMATORY AND IMMUNE SYSTEM DISORDERS | NOVARTIS AG (CH) | 2012-01-25 | — | — | EP | disclosed |