Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP15 | Q460N3 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2736806 | 0.88 | PARP15 (0.44) | PARP15PARP10PARP3 | |
| SCHEMBL2736916 | 0.87 | GABRA1 (0.46) | SMN1; SMN2 | |
| SCHEMBL12309519 | 0.87 | — | — | |
| SCHEMBL2737089 | 0.84 | MAPT (0.44) | SMN1; SMN2HSD17B10PTPN11MAPTLMNA | |
| SCHEMBL2737112 | 0.81 | TDP1 (0.47) | SMN1; SMN2HSD17B10PTPN11LMNA | |
| SCHEMBL2736681 | 0.80 | SMN1; SMN2 (0.46) | SMN1; SMN2HSD17B10PTPN11MAPTLMNA | |
| SCHEMBL2737114 | 0.79 | TDP1 (0.43) | SMN1; SMN2HSD17B10LMNAPOLB | |
| SCHEMBL2737105 | 0.79 | CA12 (0.51) | SMN1; SMN2HSD17B10MAPTLMNA | |
| SCHEMBL2736511 | 0.77 | HPGD (0.47) | SMN1; SMN2MAPTLMNAIDO1 | |
| SCHEMBL2737111 | 0.76 | MAPT (0.49) | SMN1; SMN2MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402314-A1 | (Aza)indole derivative and use thereof for medical purposes | Kissei Pharmaceutical Co., Ltd. (JP) | 2012-01-04 | — | — | EP | disclosed |