Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2737112 | 0.87 | TDP1 (0.47) | SMN1; SMN2HSD17B10PTPN11LMNAL3MBTL1 | |
| SCHEMBL12309500 | 0.85 | — | — | |
| SCHEMBL2737114 | 0.83 | TDP1 (0.43) | SMN1; SMN2HSD17B10LMNAPOLBL3MBTL1 | |
| SCHEMBL2736916 | 0.83 | GABRA1 (0.46) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2737105 | 0.81 | CA12 (0.51) | SMN1; SMN2HSD17B10MEN1KMT2ALMNA | |
| SCHEMBL2737089 | 0.80 | MAPT (0.44) | SMN1; SMN2HSD17B10PTPN11LMNAPOLB | |
| SCHEMBL10207668 | 0.80 | PARP15 (0.41) | SMN1; SMN2HSD17B10PTPN11LMNAPOLB | |
| SCHEMBL2736511 | 0.79 | HPGD (0.47) | SMN1; SMN2KMT2ALMNAALDH1A1TSHR | |
| SCHEMBL2736546 | 0.78 | LMNA (0.44) | SMN1; SMN2LMNAALDH1A1TSHRESR2 | |
| SCHEMBL10207671 | 0.77 | EGFR (0.48) | SMN1; SMN2MEN1KMT2ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402314-A1 | (Aza)indole derivative and use thereof for medical purposes | Kissei Pharmaceutical Co., Ltd. (JP) | 2012-01-04 | — | — | EP | disclosed |