Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.65 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.53 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.53 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.53 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | BACE1 | P56817 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17338557 | 0.88 | LMNA (0.61) | LMNAKDM4EHSD17B10GABRA1GABRB2 | |
| SCHEMBL17338620 | 0.88 | LMNA (0.61) | LMNAKDM4EHSD17B10GABRA1GABRB2 | |
| SCHEMBL1019952 | 0.85 | GABRA1 (0.53) | LMNAKDM4EHSD17B10GABRA1GABRB2 | |
| SCHEMBL1022143 | 0.84 | GABRA1 (0.61) | LMNAKDM4EHSD17B10GABRA1GABRB2 | |
| SCHEMBL16758472 | 0.82 | GABRA1 (0.56) | LMNAKDM4EHSD17B10GABRA1GABRB2 | |
| SCHEMBL5671316 | 0.81 | GABRA1 (0.60) | LMNAKDM4EHSD17B10GABRA1GABRB2 | |
| SCHEMBL1021821 | 0.81 | GABRA1 (0.80) | HSD17B10GABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL1020625 | 0.80 | LMNA (0.48) | LMNAKDM4EHSD17B10GABRA1GABRB2 | |
| SCHEMBL6229466 | 0.80 | LMNA (0.69) | LMNAKDM4EHSD17B10GABRA1GABRB2 | |
| SCHEMBL1020536 | 0.79 | LMNA (0.48) | LMNAKDM4EHSD17B10GABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954274-B8 | SUBSTITUTED QUINOLONES AND METHODS OF USE | CHEMOCENTRYX INC (US) | 2011-01-12 | — | — | EP | disclosed |
| EP-1954274-A4 | SUBSTITUTED QUINOLONES AND METHODS OF USE | CHEMOCENTRYX INC (US) | 2009-01-07 | — | — | EP | disclosed |
| EP-1954274-A2 | SUBSTITUTED QUINOLONES AND METHODS OF USE | ChemoCentryx Inc (US) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007059108-A2 | SUBSTITUTED QUINOLONES AND METHODS OF USE | CHEMOCENTRYX, INC. (US) | 2007-05-24 | — | — | WO | disclosed |