Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.54 |
| ▸ | SMO | Q99835 | 1/20 | 0.54 |
| ▸ | GRM5 | P41594 | 1/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.50 |
| ▸ | WNT1 | P04628 | 3/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.50 |
| ▸ | KMO | O15229 | 1/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | KDM5A | P29375 | 1/20 | 0.46 |
| ▸ | HRH2 | P25021 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10212594 | 0.89 | ALDH1A1 (0.58) | GRM5ALDH1A1MAPTL3MBTL1HDAC4 | |
| SCHEMBL10210729 | 0.87 | USP30 (0.70) | USP30PIK3CDCHEK1DRD2DRD4 | |
| SCHEMBL10210831 | 0.84 | USP30 (0.60) | USP30PIK3CDCHEK1DRD2DRD4 | |
| SCHEMBL10212633 | 0.83 | USP30 (0.56) | USP30GRM5PIK3CDCHEK1DRD2 | |
| SCHEMBL10212606 | 0.83 | USP30 (0.59) | USP30GRM5CHEK1DRD2DRD4 | |
| SCHEMBL10224770 | 0.81 | ALDH1A1 (0.61) | GRM5ALDH1A1MAPTL3MBTL1HDAC4 | |
| SCHEMBL357738 | 0.81 | ALDH1A1 (0.61) | GRM5ALDH1A1MAPTL3MBTL1HDAC4 | |
| SCHEMBL10210844 | 0.80 | SMYD2 (0.57) | USP30PIK3CDCHEK1DRD2DRD4 | |
| SCHEMBL10210732 | 0.79 | NPC1 (0.51) | USP30GRM5CHEK1L3MBTL1HDAC4 | |
| SCHEMBL10211606 | 0.79 | SMYD3 (0.59) | USP30GRM5CHEK1L3MBTL1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120082702-A1 | NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS | BRISTOL-MEYERS SQUIBB COMPANY | 2012-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120082702-A1 | NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS | NADK, BTK, NAMPT | USP30 4807/4885SMO 3513/4885GRM5 2730/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.