Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.53 |
| ▸ | CHRNB2 | P17787 | 6/20 | 0.52 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.52 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.51 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL357812 | 0.92 | SMYD3 (0.52) | SMYD3CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL9374778 | 0.84 | NPC1 (0.50) | SMYD3NPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL10211624 | 0.82 | EPHX2 (0.51) | HDAC4HDAC6NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL22883817 | 0.82 | NPC1 (0.71) | NPC1RAB9ASMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL9911611 | 0.80 | NPC1 (0.59) | SMYD3NPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL10210725 | 0.78 | CHRNB2 (0.50) | CHRNB2CHRNA4CHRNB4CHRNA3HDAC4 | |
| SCHEMBL23507363 | 0.77 | SMYD3 (0.71) | SMYD3NPC1RAB9A | |
| SCHEMBL19306739 | 0.77 | SMYD3 (0.71) | SMYD3NPC1RAB9A | |
| SCHEMBL23507338 | 0.77 | SMYD3 (0.71) | SMYD3NPC1RAB9A | |
| SCHEMBL10211623 | 0.76 | TAS1R3 (0.50) | CHRNB2CHRNA4CHRNB4CHRNA3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120082702-A1 | NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS | BRISTOL-MEYERS SQUIBB COMPANY | 2012-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120082702-A1 | NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS | NADK, BTK, NAMPT | SMYD3 4250/4885CHRNB2 2261/4885CHRNA4 2418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.