Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FUCA1 | P04066 | 2/20 | 0.60 |
| ▸ | KDM1A | O60341 | 1/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.51 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.51 |
| ▸ | ACHE | P22303 | 2/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.50 |
| ▸ | GBA1 | P04062 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13783796 | 1.00 | FUCA1 (0.60) | FUCA1KDM1ASIGMAR1DRD2DRD3 | |
| SCHEMBL12372536 | 1.00 | FUCA1 (0.60) | FUCA1KDM1ASIGMAR1DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL15751188 | 0.98 | FUCA1 (0.58) | FUCA1KDM1ASIGMAR1DRD2DRD3 | |
| SCHEMBL5242542 | 0.91 | FUCA1 (0.64) | FUCA1KDM1ASIGMAR1DRD2DRD3 | |
| SCHEMBL23939426 | 0.88 | FUCA1 (0.68) | FUCA1KDM1ASIGMAR1DRD2DRD3 | |
| SCHEMBL22796181 | 0.88 | ACHE (0.58) | FUCA1KDM1ASIGMAR1DRD2DRD3 | |
| SCHEMBL4090277 | 0.88 | KDM1A (0.54) | FUCA1KDM1ASIGMAR1DRD2DRD3 | |
| SCHEMBL20858838 | 0.88 | FUCA1 (0.53) | FUCA1KDM1ASIGMAR1DRD2DRD3 | |
| SCHEMBL21561563 | 0.88 | FUCA1 (0.68) | FUCA1KDM1ASIGMAR1DRD2DRD3 | |
| SCHEMBL13291911 | 0.88 | ACHE (0.58) | FUCA1KDM1ASIGMAR1DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 103 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0007128-B1 | DERIVATIVES OF 3-AZABICYCLO(3.1.0)HEXANE AND PROCESSES FOR THEIR PREPARATION | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1983-02-16 | — | — | EP | claimed |
| EP-0008813-B1 | PROCESSES FOR THE PREPARATION OF 3-AZABICYCLO(3.1.0)HEXANE DERIVATIVES | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1982-12-01 | — | — | EP | claimed |
| EP-0008813-A1 | Processes for the preparation of 3-azabicyclo(3.1.0)hexane derivatives | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1980-03-19 | — | — | EP | claimed |
| EP-0007128-A1 | Derivatives of 3-azabicyclo(3.1.0)hexane and processes for their preparation | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1980-01-23 | — | — | EP | claimed |
| US-4183857-A | 3-Benzyl-3-azabicyclo(3.1.0)hexane-2,4-dione | SHELL OIL COMPANY (US) | 1980-01-15 | — | — | US | claimed |
| US-12459927-B2 | Plasma kallikrein inhibitors | MERCK SHARP & DOHME LLC (US) | 2025-11-04 | — | — | US | disclosed |
| CN-115989224-B | Plasma kallikrein inhibitors | 默沙东有限责任公司 | 2025-02-25 | — | — | CN | disclosed |
| US-20230286958-A1 | PLASMA KALLIKREIN INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2023-09-14 | — | — | US | disclosed |
| EP-3856735-B1 | FUSED BICYCLIC HETEROCYCLES AS THERAPEUTIC AGENTS | UNIV NEW YORK (US) | 2023-09-06 | — | — | EP | disclosed |
| EP-4164634-A1 | PLASMA KALLIKREIN INHIBITORS | Merck Sharp & Dohme LLC (US) | 2023-04-19 | — | — | EP | disclosed |
| EP-3291810-B1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI FOUNDATION INC (US) | 2022-08-10 | — | — | EP | disclosed |
| WO-2021257353-A1 | PLASMA KALLIKREIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-12-23 | — | — | WO | disclosed |
| WO-2004052857-A1 | 3,6-DISUBSTITUTED AZABICYCLO [3.1.0] HEXANE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS | RANBAXY LABORATORIES LIMITED (IN) | 2004-06-24 | — | — | WO | disclosed |
| EP-0413455-A2 | Azabicyclo quinolone carboxylic acids | PFIZER INC. (US) | 1991-02-20 | — | — | EP | disclosed |
| EP-0007128-B1 | DERIVATIVES OF 3-AZABICYCLO(3.1.0)HEXANE AND PROCESSES FOR THEIR PREPARATION | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1983-02-16 | — | — | EP | disclosed |
| EP-0008813-B1 | PROCESSES FOR THE PREPARATION OF 3-AZABICYCLO(3.1.0)HEXANE DERIVATIVES | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1982-12-01 | — | — | EP | disclosed |
| EP-0007128-A1 | Derivatives of 3-azabicyclo(3.1.0)hexane and processes for their preparation | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1980-01-23 | — | — | EP | disclosed |
| EP-0007128-A1 | Derivatives of 3-azabicyclo(3.1.0)hexane and processes for their preparation | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1980-01-23 | — | — | EP | disclosed |
| US-4183857-A | 3-Benzyl-3-azabicyclo(3.1.0)hexane-2,4-dione | SHELL OIL COMPANY (US) | 1980-01-15 | — | — | US | disclosed |
| US-4183857-A | 3-Benzyl-3-azabicyclo(3.1.0)hexane-2,4-dione | SHELL OIL COMPANY (US) | 1980-01-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230286958-A1 | PLASMA KALLIKREIN INHIBITORS | KLKB1, SERPINE1, KLK5 | FUCA1 399/4885KDM1A 881/4885SIGMAR1 4852/4885 |
| US-12459927-B2 | Plasma kallikrein inhibitors | KLKB1, SERPINE1, KLK5 | FUCA1 399/4885KDM1A 881/4885SIGMAR1 4852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.