Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FUCA1 | P04066 | 2/20 | 0.68 |
| ▸ | GBA1 | P04062 | 1/20 | 0.57 |
| ▸ | KDM1A | O60341 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.50 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21561563 | 1.00 | FUCA1 (0.68) | FUCA1GBA1KDM1AALDH1A1GRIN2B | |
| SCHEMBL22784440 | 0.89 | FUCA1 (0.69) | FUCA1GBA1ALDH1A1GRIN2BSIGMAR1 | |
| SCHEMBL22784542 | 0.89 | FUCA1 (0.69) | FUCA1GBA1ALDH1A1GRIN2BSIGMAR1 | |
| SCHEMBL288640 | 0.89 | FUCA1 (0.69) | FUCA1GBA1ALDH1A1GRIN2BSIGMAR1 | |
| SCHEMBL15996691 | 0.89 | FUCA1 (0.69) | FUCA1GBA1ALDH1A1GRIN2BSIGMAR1 | |
| SCHEMBL758420 | 0.89 | FUCA1 (0.69) | FUCA1GBA1ALDH1A1GRIN2BSIGMAR1 | |
| SCHEMBL12371118 | 0.89 | FUCA1 (0.68) | FUCA1GBA1ALDH1A1GRIN2BSIGMAR1 | |
| SCHEMBL1707725 | 0.89 | FUCA1 (0.68) | FUCA1GBA1ALDH1A1GRIN2BSIGMAR1 | |
| SCHEMBL1707693 | 0.89 | FUCA1 (0.68) | FUCA1GBA1ALDH1A1GRIN2BSIGMAR1 | |
| SCHEMBL1707691 | 0.89 | FUCA1 (0.68) | FUCA1GBA1ALDH1A1GRIN2BSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12030897-B2 | Pyrrolo[2,1-f][1,2,4]triazine derivatives serving as selective HER2 inhibitors and application thereof | MEDSHINE DISCOVERY INC. (CN) | 2024-07-09 | — | — | US | disclosed |
| US-12030897-B2 | Pyrrolo[2,1-f][1,2,4]triazine derivatives serving as selective HER2 inhibitors and application thereof | MEDSHINE DISCOVERY INC. (CN) | 2024-07-09 | — | — | US | disclosed |
| US-20210323979-A1 | PYRROLO[2,1-F][1,2,4]TRIAZINE DERIVATIVES SERVING AS SELECTIVE HER2 INHIBITORS AND APPLICATION THEREOF | MEDSHINE DISCOVERY INC. (CN) | 2021-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12030897-B2 | Pyrrolo[2,1-f][1,2,4]triazine derivatives serving as selective HER2 inhibitors and application thereof | ERBB2, EGFR, ERBB3 | FUCA1 1690/4885GBA1 2163/4885KDM1A 2018/4885 |
| US-20210323979-A1 | PYRROLO[2,1-F][1,2,4]TRIAZINE DERIVATIVES SERVING AS SELECTIVE HER2 INHIBITORS AND APPLICATION THEREOF | ERBB2, EGFR, ERBB3 | FUCA1 1690/4885GBA1 2163/4885KDM1A 2018/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.