Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 4/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.38 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14493294 | 0.90 | MET (0.55) | METKCNH2MAP4K4ALKMAP4K3 | |
| SCHEMBL10218074 | 0.85 | MET (0.60) | METKCNH2MAP4K4PAX8 | |
| SCHEMBL10218076 | 0.83 | MET (0.64) | METMAP4K4PAX8MAP4K3 | |
| SCHEMBL10218132 | 0.83 | MET (0.52) | METKCNH2MAP4K4MAP4K3 | |
| SCHEMBL10218274 | 0.83 | MET (0.56) | METKCNH2MAP4K4MAP4K3 | |
| SCHEMBL10218367 | 0.82 | MET (0.57) | METKCNH2MAP4K4PAX8MAP4K3 | |
| SCHEMBL10218122 | 0.82 | MET (0.56) | METKCNH2MAP4K4PAX8MAP4K3 | |
| SCHEMBL10218167 | 0.81 | MET (0.56) | METKCNH2MAP4K4MAP4K3 | |
| SCHEMBL10215501 | 0.81 | MET (0.56) | METKCNH2MAP4K4MAP4K3 | |
| SCHEMBL488207 | 0.81 | MET (0.56) | METKCNH2MAP4K4MAP4K3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106197-B2 | Aminoheteroaryl compounds as protein kinase inhibitors | PFIZER INC. (US) | 2012-01-31 | — | — | US | disclosed |
| US-8106197-B2 | Aminoheteroaryl compounds as protein kinase inhibitors | PFIZER INC. (US) | 2012-01-31 | — | — | US | disclosed |
| US-20070072874-A1 | Aminoheteroaryl compounds as protein kinase inhibitors | SUGEN, INC. | 2007-03-29 | — | — | US | disclosed |
| US-20070072874-A1 | Aminoheteroaryl compounds as protein kinase inhibitors | SUGEN, INC. | 2007-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070072874-A1 | Aminoheteroaryl compounds as protein kinase inhibitors | MET, MAP4K1, MAP4K2 | MET 1/4885KCNH2 2515/4885MAP4K4 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.