Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 10/20 | 0.55 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10218294 | 0.90 | MET (0.51) | METMAP4K3KCNH2MAP4K4ALK | |
| SCHEMBL10218076 | 0.90 | MET (0.64) | METMAP4K3MAP4K4 | |
| SCHEMBL10218367 | 0.89 | MET (0.57) | METMAP4K3KCNH2MAP4K4 | |
| SCHEMBL10218122 | 0.88 | MET (0.56) | METMAP4K3KCNH2MAP4K4 | |
| SCHEMBL10218074 | 0.88 | MET (0.60) | METKCNH2MAP4K4 | |
| SCHEMBL10218274 | 0.88 | MET (0.56) | METMAP4K3KCNH2MAP4K4 | |
| SCHEMBL10218132 | 0.88 | MET (0.52) | METMAP4K3KCNH2MAP4K4 | |
| SCHEMBL10218167 | 0.86 | MET (0.56) | METMAP4K3KCNH2MAP4K4 | |
| SCHEMBL10218126 | 0.85 | MET (0.61) | METKCNH2MAP4K4 | |
| SCHEMBL10215501 | 0.85 | MET (0.56) | METMAP4K3KCNH2MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7230098-B2 | 2-amino- pyridines and pyrazines additionally substituted witn one or more carbocyclic or heterocyclic groups, e.g., 4-[6-amino-5-(2,6-dichloro-benzyloxy)-pyridin-3-yl]-phenol, for treating many kinds of cancer | SUGEN, INC. (US) | 2007-06-12 | — | — | US | disclosed |
| US-7230098-B2 | 2-amino- pyridines and pyrazines additionally substituted witn one or more carbocyclic or heterocyclic groups, e.g., 4-[6-amino-5-(2,6-dichloro-benzyloxy)-pyridin-3-yl]-phenol, for treating many kinds of cancer | SUGEN, INC. (US) | 2007-06-12 | — | — | US | disclosed |