Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.38 |
| ▸ | LSS | P48449 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1075172 | 0.90 | ACKR3 (0.40) | KDM4EALDH1A1LMNASMN1; SMN2GAA | |
| Trifluoroacetic Acid SCHEMBL1021864 | 0.81 | PRKAB2 (0.47) | KDM4EALDH1A1LMNASMN1; SMN2GAA | |
| SCHEMBL1017900 | 0.77 | MEN1 (0.53) | KDM4EALDH1A1LMNASMN1; SMN2GAA | |
| SCHEMBL3688234 | 0.74 | CHRM2 (0.46) | KDM4EALDH1A1LMNASMN1; SMN2GAA | |
| SCHEMBL28052665 | 0.74 | MEN1 (0.53) | KDM4EALDH1A1LMNASMN1; SMN2GAA | |
| Trifluoroacetic Acid SCHEMBL1018638 | 0.74 | PRKAB2 (0.48) | KDM4EALDH1A1LMNASMN1; SMN2GAA | |
| SCHEMBL1019016 | 0.73 | SMN1; SMN2 (0.54) | KDM4EALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL1018777 | 0.73 | MEN1 (0.57) | KDM4EALDH1A1LMNASMN1; SMN2GAA | |
| SCHEMBL1023329 | 0.73 | HPGD (0.45) | KDM4EALDH1A1LMNASMN1; SMN2GAA | |
| Trifluoroacetic Acid SCHEMBL1075170 | 0.73 | BCHE (0.49) | KDM4EALDH1A1LMNASMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2190827-B1 | N-BENZYL-N'-ARYLCARBONYLPIPERAZINE DERIVATIVES AS LXR MODULATORS | ORGANON NV (NL) | 2011-01-12 | — | — | EP | disclosed |
| EP-2190827-A1 | N-BENZYL, N' -ARYLCARBONYLPIPERAZINE DERIVATIVES AS LXR MODULATORS | N.V. Organon (NL) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009024550-A1 | N-BENZYL, N' -ARYLCARBONYLPIPERAZINE DERIVATIVES AS LXR MODULATORS | N.V. ORGANON (NL) | 2009-02-26 | — | — | WO | disclosed |