SCHEMBL1021868

SCHEMBL1021868

c1ccc2c(c1)CCN2c1cc2ccccc2o1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CD74 P04233 1/20 0.53
MIF P14174 1/20 0.53
ROCK1 Q13464 1/20 0.42
SMN1; SMN2 Q16637 2/20 0.41
TP53 P04637 2/20 0.40
LMNA P02545 1/20 0.40
MAPK1 P28482 1/20 0.40
ALDH1A1 P00352 4/20 0.40
NPC1 O15118 3/20 0.40
RAB9A P51151 2/20 0.40
HPGD P15428 2/20 0.40
RXFP1 Q9HBX9 1/20 0.40
HSD17B10 Q99714 1/20 0.39
NPSR1 Q6W5P4 2/20 0.39
ALOX15 P16050 2/20 0.39
TSHR P16473 2/20 0.39
BRCA1 P38398 1/20 0.39
SRD5A1 P18405 2/20 0.39
KMT2A Q03164 3/20 0.39
MEN1 O00255 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17179428 0.71 CHRNA7 (0.46) CD74MIFROCK1SMN1; SMN2TP53
SCHEMBL1019181 0.70 NPC1 (0.49) ROCK1SMN1; SMN2TP53LMNAMAPK1
SCHEMBL2757847 0.70 CD74 (1.00) CD74MIFSMN1; SMN2LMNAMAPK1
SCHEMBL27581467 0.69 PRKDC (0.50) SMN1; SMN2TP53MAPK1ALDH1A1NPC1
SCHEMBL19117986 0.69 SRD5A1 (0.56) ROCK1SMN1; SMN2TP53LMNAMAPK1
SCHEMBL3512413 0.68 ALDH1A1 (0.51) SMN1; SMN2TP53MAPK1ALDH1A1NPC1
SCHEMBL21047713 0.68 PRKDC (0.52) CD74MIFSMN1; SMN2LMNAALDH1A1
SCHEMBL27059092 0.67 ALDH1A1 (0.50) ROCK1SMN1; SMN2TP53LMNAMAPK1
SCHEMBL16470017 0.67 PRKDC (0.67) SMN1; SMN2TP53LMNAMAPK1ALDH1A1
SCHEMBL3511781 0.67 PRKDC (0.44) SMN1; SMN2TP53LMNAALDH1A1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0010063-B1 PROCESS FOR THE PREPARATION OF FURANYL-BENZAZOLES CIBA-GEIGY AG (CH) 1982-12-29 EP claimed
EP-0010063-A2 Process for the preparation of furanyl-benzazoles CIBA-GEIGY AG (CH) 1980-04-16 EP claimed
EP-4114347-A1 COSMETIC COMPOSITION FOR FORMING A FILM HAVING ELEVATED ELASTICITY AND EXTENSIBILITY Covestro Deutschland AG (DE) 2023-01-11 EP disclosed
EP-3177267-B1 POLYURETHANEUREA SOLUTIONS FOR COSMETIC COMPOSITIONS COVESTRO DEUTSCHLAND AG (DE) 2022-01-05 EP disclosed
EP-3889196-A1 BIOBASED POLYURETHANE DISPERSIONS FOR SUNSCREEN APPLICATIONS Covestro Deutschland AG (DE) 2021-10-06 EP disclosed
EP-3888627-A1 BIO-BASED POLYURETHANE DISPERSIONS FOR DECORATIVE COSMETIC APPLICATIONS Covestro Deutschland AG (DE) 2021-10-06 EP disclosed
EP-2271307-B1 SKIN CARE COMPOSITION COVESTRO DEUTSCHLAND AG (DE) 2019-11-20 EP disclosed
EP-2271305-B1 SUNSCREEN COMPOSITIONS COVESTRO DEUTSCHLAND AG (DE) 2019-09-04 EP disclosed
EP-2271306-B1 DECORATIVE COSMETIC COMPOUNDS COVESTRO DEUTSCHLAND AG (DE) 2019-08-28 EP disclosed
EP-2542212-B1 SUN PROTECTION COMPOSITIONS COVESTRO DEUTSCHLAND AG (DE) 2018-02-21 EP disclosed
EP-2457846-A2 Dispensing module for cosmetic compounds Bayer MaterialScience AG (DE) 2012-05-30 EP disclosed
WO-2012049146-A2 POLYURETHANE-BASED SUNSCREEN COMPOSITION CONTAINING SPECIAL FILTER SUBSTANCES BAYER MATERIALSCIENCE AG (DE) 2012-04-19 WO disclosed
EP-2271307-A2 SKIN CARE COMPOSITION Bayer MaterialScience AG (DE) 2011-01-12 EP disclosed
EP-2106833-A1 Particle derived from drying a liquid nano-uric dispersion Bayer MaterialScience AG (DE) 2009-10-07 EP disclosed
WO-2009118107-A2 SKIN CARE COMPOSITION BAYER MATERIALSCIENCE AG (DE) 2009-10-01 WO disclosed
EP-2105126-A1 Decorative cosmetic compounds Bayer MaterialScience AG (DE) 2009-09-30 EP disclosed
EP-2105125-A1 Skin care composition Bayer MaterialScience AG (DE) 2009-09-30 EP disclosed
EP-2105124-A1 Sunscreen compositions Bayer MaterialScience AG (DE) 2009-09-30 EP disclosed
EP-0010063-B1 PROCESS FOR THE PREPARATION OF FURANYL-BENZAZOLES CIBA-GEIGY AG (CH) 1982-12-29 EP disclosed
EP-0010063-A2 Process for the preparation of furanyl-benzazoles CIBA-GEIGY AG (CH) 1980-04-16 EP disclosed