Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 4/20 | 0.47 |
| ▸ | MMP2 | P08253 | 4/20 | 0.47 |
| ▸ | MMP9 | P14780 | 4/20 | 0.47 |
| ▸ | MMP12 | P39900 | 4/20 | 0.47 |
| ▸ | MMP14 | P50281 | 4/20 | 0.47 |
| ▸ | MMP15 | P51511 | 4/20 | 0.47 |
| ▸ | MMP16 | P51512 | 4/20 | 0.47 |
| ▸ | MMP26 | Q9NRE1 | 4/20 | 0.47 |
| ▸ | MMP7 | P09237 | 3/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 4/20 | 0.42 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1021485 | 0.94 | CACNA1B (0.43) | MMP1MMP2MMP9MMP12MMP14 | |
| SCHEMBL1022854 | 0.93 | MMP1 (0.48) | MMP1MMP2MMP9MMP12MMP14 | |
| SCHEMBL1021032 | 0.93 | MMP1 (0.49) | MMP1MMP2MMP9MMP12MMP14 | |
| SCHEMBL3534142 | 0.88 | MMP1 (0.52) | MMP1MMP2MMP9MMP12MMP14 | |
| SCHEMBL1022853 | 0.87 | MMP1 (0.53) | MMP1MMP2MMP9MMP12MMP14 | |
| SCHEMBL1021988 | 0.86 | MMP1 (0.63) | MMP1MMP2MMP9MMP12MMP14 | |
| SCHEMBL1021792 | 0.85 | TBXAS1 (0.44) | MMP1MMP2MMP9MMP12MMP14 | |
| SCHEMBL1021283 | 0.85 | ESR1 (0.53) | MMP1MMP2MMP9MMP12MMP14 | |
| SCHEMBL1021990 | 0.85 | CACNA1B (0.43) | MMP1MMP2MMP9MMP12MMP14 | |
| SCHEMBL1020994 | 0.83 | MMP1 (0.50) | MMP1MMP2MMP9MMP12MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869001-B1 | SUBSTITUTED TETRAHYDROISOCHINOLINES AS MMP INHIBITORS, RELATED PRODUCTION METHOD AND USE AS MEDICINE | SANOFI AVENTIS (FR) | 2011-01-12 | — | — | EP | disclosed |