Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 3/20 | 0.44 |
| ▸ | UBE2M | P61081 | 2/20 | 0.44 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | SCN1A | P35498 | 1/20 | 0.44 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1022217 | 0.88 | KDM4E (0.51) | CYP3A4KDM4EALDH1A1GAALMNA | |
| SCHEMBL1022588 | 0.88 | KDM4E (0.51) | CYP3A4KDM4EALDH1A1GAALMNA | |
| SCHEMBL1022629 | 0.87 | CXCR3 (0.43) | CYP3A4KCNH2UBE2MDCUN1D1SCN8A | |
| SCHEMBL4997273 | 0.85 | DRD2 (0.49) | CYP3A4ALDH1A1LMNAKCNH2SIGMAR1 | |
| SCHEMBL27718065 | 0.85 | SLC2A1 (0.41) | CYP3A4KDM4EALDH1A1GAALMNA | |
| SCHEMBL1021639 | 0.83 | JAK2 (0.47) | KCNH2SCN1ASCN8AJAK2JAK1 | |
| SCHEMBL1022659 | 0.82 | JAK2 (0.45) | KCNH2DRD4SCN1ASCN8AJAK2 | |
| SCHEMBL1021367 | 0.82 | CXCR3 (0.40) | CYP3A4KCNH2DCUN1D1PIM1SCN1A | |
| SCHEMBL1019624 | 0.82 | DRD3 (0.45) | KDM4EALDH1A1KCNH2SIGMAR1DRD4 | |
| SCHEMBL5005077 | 0.81 | MAP4K4 (0.43) | CYP3A4ALDH1A1LMNAKCNH2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9751860-B2 | Piperidin-4YL-pyridazin-3-ylamine derivatives as fast dissociating dopamine 2 receptor antagonists | JANSSEN PHARMACEUTICA NV (BE) | 2017-09-05 | — | — | US | disclosed |
| US-20170022181-A1 | FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | DE BRUYN MARCEL FRANS LEOPOLD (BE) | 2017-01-26 | — | — | US | disclosed |
| US-9468640-B2 | Piperidin-4-yl-pyridazin-3-ylamine derivatives as fast dissociating dopamine 2 receptor antagonists | JANSSEN PHARMACEUTICA NV (BE) | 2016-10-18 | — | — | US | disclosed |
| US-20150141432-A1 | PIPERIDIN-4-YL-PYRIDAZIN-3-YLAMINE DERIVATIVES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2015-05-21 | — | — | US | disclosed |
| US-8940743-B2 | Piperidin-4-yl-pyridazin-3-ylamine derivatives as fast dissociating dopamine 2 receptor antagonists | JANSSEN PHARMACEUTICA NV (BE) | 2015-01-27 | — | — | US | disclosed |
| CN-101291925-B | Piperidin-4-yl-pyridazin-3-ylamine derivatives as fast dissociating dopamine 2 receptor antagonists | JANSSEN PHARMACEUTICA NV | 2013-04-10 | — | — | CN | disclosed |
| EP-1943242-B1 | PIPERIDIN-4-YL-PYRIDAZIN-3-YLAMINE DERIVATIVES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2011-01-12 | — | — | EP | disclosed |
| CN-101291925-A | Piperidin-4-yl-pyridazin-3-ylamine derivatives as fast dissociating dopamine 2 receptor antagonists | JANSSEN PHARMACEUTICA NV (BE) | 2008-10-22 | — | — | CN | disclosed |
| US-20080227791-A1 | treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects; N-[1-(4-fluorobenzyl)piperidin-4-yl]-6-(trifluoromethyl)pyridazin-3-amine | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170022181-A1 | FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | DRD2, GRIN2A, GRIN2C | CYP3A4 2083/4885KDM4E 2968/4885ALDH1A1 2166/4885 |
| US-20080227791-A1 | treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects; N-[1-(4-fluorobenzyl)piperidin-4-yl]-6-(trifluoromethyl)pyridazin-3-amine | GRIN2C, GRIN2A, GRIN3A | CYP3A4 1968/4885KDM4E 2792/4885ALDH1A1 1819/4885 |
| US-20150141432-A1 | PIPERIDIN-4-YL-PYRIDAZIN-3-YLAMINE DERIVATIVES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | DRD2, GRIN2C, GRIN2A | CYP3A4 1643/4885KDM4E 1691/4885ALDH1A1 1949/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.