SCHEMBL10224985

SCHEMBL10224985

O=C(NC12CC3CC(CC1C3)C2)C(F)(F)SOOO

nearest known ligand 0.37

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 4/20 0.37
CACNA1H O95180 1/20 0.33
EPHX1 P07099 1/20 0.31
CNR1 P21554 1/20 0.31
CNR2 P34972 1/20 0.31
DPP4 P27487 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10224986 0.84 EPHX2 (0.44) EPHX2EPHX1
SCHEMBL10224951 0.83 EPHX2 (0.38) EPHX2CACNA1HEPHX1CNR1CNR2
SCHEMBL10224979 0.75 ALDH1A1 (0.47) EPHX2
SCHEMBL10224980 0.75 ALDH1A1 (0.41) EPHX2CNR1CNR2DPP4
SCHEMBL10224989 0.74 ALDH1A1 (0.50) EPHX2
SCHEMBL2602946 0.71 CYP19A1 (0.36) EPHX2
SCHEMBL10272965 0.71 EPHX2 (0.40) EPHX2CACNA1HEPHX1CNR1CNR2
SCHEMBL10224990 0.70 EPHX2 (0.41) EPHX2EPHX1
SCHEMBL10225003 0.69 EPHX2 (0.45) EPHX2
SCHEMBL2602928 0.69 MEN1 (0.45) EPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8148044-B2 Positive photosensitive composition FUJIFILM CORPORATION (JP) 2012-04-03 US disclosed
US-20100136479-A1 POSITIVE PHOTOSENSITIVE COMPOSITION FUJIFILM CORPORATION (JP) 2010-06-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100136479-A1 POSITIVE PHOTOSENSITIVE COMPOSITION AFF1, F12, AFF2 EPHX2 1401/4885CACNA1H 3249/4885EPHX1 2075/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.