SCHEMBL1023199

SCHEMBL1023199

CCN(CC)CCOc1ccc2c(c1)CCN(S(=O)(=O)c1ccc(Oc3ccc(OC)cc3)cc1)C2OC(=O)O

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP1 P03956 6/20 0.51
MMP9 P14780 6/20 0.51
MMP2 P08253 5/20 0.51
MMP12 P39900 5/20 0.51
MMP14 P50281 5/20 0.51
MMP15 P51511 5/20 0.51
MMP16 P51512 5/20 0.51
MMP26 Q9NRE1 5/20 0.51
MMP7 P09237 4/20 0.51
TAS2R14 Q9NYV8 2/20 0.47
SLC6A4 P31645 1/20 0.42
HRH3 Q9Y5N1 1/20 0.42
PPARD Q03181 2/20 0.42
HCRTR1 O43613 1/20 0.41
HCRTR2 O43614 1/20 0.41
CA1 P00915 2/20 0.40
CA2 P00918 2/20 0.40
CA7 P43166 2/20 0.40
CA9 Q16790 2/20 0.40
CA14 Q9ULX7 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1020994 0.93 MMP1 (0.50) MMP1MMP9MMP2MMP12MMP14
SCHEMBL1021054 0.93 MMP1 (0.43) MMP1MMP9MMP2MMP12MMP14
SCHEMBL1024080 0.91 MMP1 (0.53) MMP1MMP9MMP2MMP12MMP14
SCHEMBL1023198 0.88 MMP1 (0.56) MMP1MMP9MMP2MMP12MMP14
SCHEMBL1020703 0.86 MMP1 (0.43) MMP1MMP9MMP2MMP12MMP14
SCHEMBL3534955 0.86 MMP1 (0.55) MMP1MMP9MMP2MMP12MMP14
SCHEMBL1023175 0.85 ESR1 (0.55) MMP1MMP9MMP2MMP12MMP14
SCHEMBL3534115 0.84 MMP1 (0.67) MMP1MMP9MMP2MMP12MMP14
SCHEMBL1021470 0.84 MMP1 (0.45) MMP1MMP9MMP2MMP12MMP14
SCHEMBL1022854 0.83 MMP1 (0.48) MMP1MMP9MMP2MMP12MMP14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1869001-B1 SUBSTITUTED TETRAHYDROISOCHINOLINES AS MMP INHIBITORS, RELATED PRODUCTION METHOD AND USE AS MEDICINE SANOFI AVENTIS (FR) 2011-01-12 EP disclosed
EP-1869001-A1 SUBSTITUTED TETRAHYDROISOCHINOLINES AS MMP INHIBITORS, RELATED PRODUCTION METHOD AND USE AS MEDICINE Sanofi-Aventis (FR) 2007-12-26 EP disclosed
WO-2006102998-A1 SUBSTITUTED TETRAHYDROISOCHINOLINES AS MMP INHIBITORS, RELATED PRODUCTION METHOD AND USE AS MEDICINE SANOFI-AVENTIS (DE) 2006-10-05 WO disclosed