Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 11/20 | 0.53 |
| ▸ | MMP9 | P14780 | 10/20 | 0.53 |
| ▸ | MMP2 | P08253 | 7/20 | 0.53 |
| ▸ | MMP7 | P09237 | 7/20 | 0.53 |
| ▸ | MMP12 | P39900 | 6/20 | 0.53 |
| ▸ | MMP14 | P50281 | 6/20 | 0.53 |
| ▸ | MMP15 | P51511 | 6/20 | 0.53 |
| ▸ | MMP16 | P51512 | 6/20 | 0.53 |
| ▸ | MMP26 | Q9NRE1 | 6/20 | 0.53 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.44 |
| ▸ | MMP13 | P45452 | 2/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 5/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 2/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1021470 | 0.93 | MMP1 (0.45) | MMP1MMP9MMP2MMP7MMP12 | |
| SCHEMBL1020994 | 0.92 | MMP1 (0.50) | MMP1MMP9MMP2MMP7MMP12 | |
| SCHEMBL1023199 | 0.91 | MMP1 (0.51) | MMP1MMP9MMP2MMP7MMP12 | |
| SCHEMBL3534115 | 0.87 | MMP1 (0.67) | MMP1MMP9MMP2MMP7MMP12 | |
| SCHEMBL1020703 | 0.86 | MMP1 (0.43) | MMP1MMP9MMP2MMP7MMP12 | |
| SCHEMBL1021277 | 0.86 | MMP1 (0.53) | MMP1MMP9MMP2MMP7MMP12 | |
| SCHEMBL3534955 | 0.85 | MMP1 (0.55) | MMP1MMP9MMP2MMP7MMP12 | |
| SCHEMBL1023198 | 0.84 | MMP1 (0.56) | MMP1MMP9MMP2MMP7MMP12 | |
| SCHEMBL1021032 | 0.84 | MMP1 (0.49) | MMP1MMP9MMP2MMP7MMP12 | |
| SCHEMBL5164250 | 0.84 | MMP1 (0.69) | MMP1MMP9MMP2MMP7MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869001-B1 | SUBSTITUTED TETRAHYDROISOCHINOLINES AS MMP INHIBITORS, RELATED PRODUCTION METHOD AND USE AS MEDICINE | SANOFI AVENTIS (FR) | 2011-01-12 | — | — | EP | disclosed |
| EP-1869001-A1 | SUBSTITUTED TETRAHYDROISOCHINOLINES AS MMP INHIBITORS, RELATED PRODUCTION METHOD AND USE AS MEDICINE | Sanofi-Aventis (FR) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006102998-A1 | SUBSTITUTED TETRAHYDROISOCHINOLINES AS MMP INHIBITORS, RELATED PRODUCTION METHOD AND USE AS MEDICINE | SANOFI-AVENTIS (DE) | 2006-10-05 | — | — | WO | disclosed |