Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | RARG | P13631 | 1/20 | 0.30 |
| ▸ | RXRA | P19793 | 1/20 | 0.30 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13458599 | 0.76 | MAPK14 (0.34) | MAPK14MAPTSMN1; SMN2BCL2A1TP53 | |
| SCHEMBL10233040 | 0.76 | MAPT (0.39) | MAPK14MAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL13456553 | 0.74 | CYP2C19 (0.30) | — | |
| SCHEMBL10233192 | 0.73 | MAPK14 (0.44) | MAPK14MAPTBCL2A1 | |
| SCHEMBL10231144 | 0.72 | AKR1C3 (0.45) | MAPK14MAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL13458591 | 0.72 | MAPK14 (0.35) | MAPK14MAPTSMN1; SMN2TP53GABRA1 | |
| SCHEMBL15086943 | 0.72 | MAPK14 (0.44) | MAPK14MAPTSMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL10231614 | 0.72 | MAPK14 (0.37) | MAPK14MAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL15086981 | 0.72 | KDM4E (0.41) | MAPK14MAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL19050448 | 0.70 | MAPK14 (0.33) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323980-B1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INT (DE) | 2012-02-29 | — | — | EP | disclosed |