Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA4 | P22748 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13623221 | 0.82 | DRD2 (0.49) | MAPTALDH1A1HTTSMN1; SMN2TDP1 | |
| SCHEMBL1027561 | 0.80 | TDP1 (0.48) | MAPTALDH1A1LMNAHTTKMT2A | |
| SCHEMBL4367577 | 0.80 | TDP1 (0.48) | MAPTALDH1A1LMNAHTTKMT2A | |
| SCHEMBL1026884 | 0.78 | ALDH1A1 (0.50) | MAPTALDH1A1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL13623225 | 0.77 | MAPT (0.45) | MAPTALDH1A1LMNAHTTKMT2A | |
| SCHEMBL1027144 | 0.74 | HTT (0.42) | MAPTALDH1A1LMNAHTTKMT2A | |
| SCHEMBL1027142 | 0.74 | HTT (0.42) | MAPTALDH1A1LMNAHTTKMT2A | |
| SCHEMBL5232224 | 0.71 | ALDH1A1 (0.51) | MAPTALDH1A1LMNAHTTKMT2A | |
| SCHEMBL4287750 | 0.71 | ALDH1A1 (0.51) | MAPTALDH1A1LMNAHTTKMT2A | |
| SCHEMBL4287745 | 0.71 | ALDH1A1 (0.51) | MAPTALDH1A1LMNAHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |
| WO-2009132202-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-10-29 | — | — | WO | disclosed |