Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.38 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1283047 | 0.86 | PIK3CA (0.47) | PIK3CAOPRD1KCNH2OPRM1GRIN2D | |
| SCHEMBL15260026 | 0.79 | TRPV1 (0.44) | PIK3CAOPRD1KCNH2OPRM1 | |
| SCHEMBL6978939 | 0.78 | GPR119 (0.44) | PIK3CAOPRD1KCNH2OPRM1OPRK1 | |
| SCHEMBL15260099 | 0.77 | PIK3CA (0.40) | PIK3CAOPRD1KCNH2OPRM1OPRK1 | |
| SCHEMBL15260220 | 0.76 | MAPT (0.43) | OPRD1KCNH2OPRM1OPRK1SLC22A1 | |
| SCHEMBL28247431 | 0.76 | CYP3A4 (0.50) | OPRD1KCNH2OPRM1OPRK1SLC22A1 | |
| SCHEMBL3315322 | 0.75 | CYP2C9 (0.51) | — | |
| SCHEMBL15260451 | 0.74 | PANK3 (0.46) | OPRD1KCNH2OPRM1OPRK1SLC22A1 | |
| SCHEMBL15260190 | 0.72 | OPRM1 (0.41) | OPRD1KCNH2OPRM1GRIN2DGRIN3B | |
| SCHEMBL28704750 | 0.71 | OPRM1 (0.55) | OPRD1KCNH2OPRM1OPRK1SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012045124-A1 | BACTERIA TOPOISOMERASE II INHIBITING 2-ETHYLCARBAMOYLAMINO-1, 3-BENZOTHIAZOL-5-YLS | BIOTA EUROPE LTD (GB) | 2012-04-12 | — | — | WO | disclosed |